Bell’s Palsy

Bell's palsy is an idiopathic LMN palsy involving the facial nerve accounting for up to 3/4 of all cases of unilateral facial paralysis. It is believed that inflammation and swelling of the facial nerve causes compression and ischemia of the nerve which manifests as facial muscle weakness. However, the exact etiology of BP is controversial; reactivated herpes simplex virus is thought to be the most probable cause followed by herpes zoster virus.

The facial nerve consists of a:
  • Motor component, which supplies all the muscle of facial expression
  • Sensory branch that carries taste sensation from the anterior two thirds of the tongue through the chorda tympani nerve
  • Parasympathetic fibres reach the lacrimal glands via the greater superficial petrosal nerve, and they reach the sublingual and submaxillary glands via the chorda tympani. 
Bell's palsy is diagnosed upon the abrupt onset of unilateral facial weakness or complete paralysis of all the muscles on one side of the face, dry eye, pain around the ear, an altered sense of taste, hyperacusis, or decreased tearing. On attempted closure, the eye rolls upward (Bell's phenomenon). The disease usually progresses from the onset of symptoms to maximal weakness within three days. 

The most widely applied is the HouseBrackmann facial nerve grading system:



UMN and LMN facial palsy





Diagnosis and Treatment 


Focus on the history and physical examination to identify the possible causes of LMN facial palsy such as:

  • Otitis media
  • Trauma
  • Postsurgical complications
  • Neoplasms
  • Sarcoidosis
  • Lyme Disease 
  • Reactivated varicella zoster virus infection of the geniculate ganglion (Ramsay Hunts syndrome). 


Corticosteroids initiated within 3 days of facial palsy onset in adults increase the likelihood of recovery, shorten the time to recovery, and reduce synkinesis. Patients with BP should not complain of any facial pain and should not have any cranial nerve involvement other than the facial nerve. Bilateral facial palsy suggests a diagnosis other than BP. 

Recent literature favors the use of steroids and not antivirals. Sullivan et al. in 2007 examined the treatment options for BP in a randomized control trial across 17 sites in Scotland. At three months, 83% of patients in the prednisolone group versus 63.6% of patients in the non-prednisolone group fully recovered. A meta-analysis in 2009 determined there was no significant benefit of combined antiviral and steroid treatment compared to steroids alone. Currently, the recommended treatment regiment for BP is prednisone, 60 to 80 mg per day, for one week or giving 25 mg twice daily for 10 days. 



Eye Care: Prescribe lubricating eye drops for use during the day in addition to a corneal lubricant to use at night. Furthermore, patches or taping the eyelid closed can be used at night. 


Severe disease can result in inability to completely close the eye in addition to decreased lacrimal secretions, leading to drying and tearing of the cornea. 

Summary

  • Bell’s palsy is idiopathic paralysis of the facial nerve and is the most common cause of LMN facial palsy. DO a full neuro exam and look for other cranila nerve involvement to look for potential brainstem CVA.
  • Bell's Palsy is unilateral and acute in onset, progressing over a period of hours and reaching maximal intensity within several days
  • Treatment consists of corticosteroids and eye care. The prognosis of BP is excellent, with 85% of patients regaining function within three weeks

References:
  1. Fahimi J, Navi BB, Kamel H. Potential misdiagnoses of Bell's palsy in the emergency department. Annals of emergency medicine. 2014 Apr 1;63(4):428-34.
  2. Sullivan FM, Swan IR, Donnan PT, Morrison JM, Smith BH, McKinstry B, Davenport RJ, Vale LD, Clarkson JE, Hammersley V, Hayavi S, McAteer A, Stewart K, Daly F. Early treatment with prednisolone or acyclovir in Bell’s palsy. N Engl J Med. 2007 Oct 18;357(16):1598-607.
  3. https://cks.nice.org.uk/bells-palsy#!scenario
  4. Quant EC, et al. The benefits of steroids versus steroids plus antivirals for treatment of Bell’s palsy: a meta-analysis. BMJ. 2009;339:b3354 

Anti-Calcitonin

The use of procalcitonin to guide antibiotic therapy has been gradually increasing over the past several years – driven, in no small part, by increased recognition of the harms of antibiotic overuse. However, what evidence we have regarding its utility is primarily derived from manufacturer-sponsored trials – including virtual carpet-bombing of the literature by their sponsored representatives.

So, what happens when the manufacturer isn’t part of the trial?

No benefit.

This is the ProACT trial, an individual-randomized comparison between a procalcitonin-guided arm and “usual care” in patients with suspected lower respiratory tract infection for whom the indication for antibiotics is unclear. Physicians caring for patients randomized to the procalcitonin arm were provided results tied to antibiotic use recommendations – “strongly discouraged”, “discouraged”, “encouraged”, “strongly encouraged” – on initial presentation in the Emergency Department, and then in serial fashion for those admitted to the hospital. In those in the “usual care” arm, procalcitonin results were obtained, but not provided to the treating clinicians.

Then: Across 14 hospitals and 1,656 patients, there were no statistically significant differences between antibiotic-free days or adverse outcomes between the two arms. Done? Done.

Except, as skeptical as I might be regarding procalcitonin-guided therapy, there are big holes in these data as the definitive word on its disutility. Unlike other trials, these centers provided only passive guidance to clinicians regarding the procalcitonin algorithm. This resulted in only 72.9% of physicians adhering to protocol, with the greatest numbers of violations being antibiotic use in patients for whom it were discouraged, including 30% of those for whom antibiotic use was “strongly discouraged”:

Even though the “per-guideline” analysis also shows no difference, this is mostly because the bulk of the procalcitonin “per-guideline” population were those who appropriately received antibiotics – effectively eliminating the possibility of showing a difference in antibiotic use.

There are a few signals within these data reflecting the potential advantages of a procalcitonin-guided algorithm, should the protocol actually be followed. There were small differences in prescribing favoring the procalcitonin arm for almost every final clinical diagnosis – excepting about 15% absolute advantages for “acute bronchitis” and for those with non-specific diagnoses. It is likely these represented the cases for which the appropriateness of antibiotics was lowest, and probably also represent the majority of protocol violations. That said, one could easily make the argument this advantage only exists as a result of culturally-ingrained poor antibiotic prescribing habits for these sorts of borderline cases.

In short, these data clearly show there is no advantage to introducing procalcitonin into practice specifically in the fashion demonstrated here – but these cannot be generalized to say a different implementation or application of procalcitonin has no value.  There is work yet to be done for both proponents and skeptics of its value.

“Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection”
https://www.nejm.org/doi/full/10.1056/NEJMoa1802670

“High Quality CPR” and You!

CPR as we know it was “invented” by numerous resuscitation scientists working in competing labs during the 1950s.  Since then, CPR has gone through a number of changes, from compression-to-ventilation rates, training programs and even the manner in which it is delivered.  In the 1990s, pubic defibrillators became mainstream.  In the mid 2000s, external CPR devices became more common and in 2010 “hands-only” CPR was the predominant layperson resuscitation method.  The latest iteration of CPR and resuscitation science is the focus on “high quality” CPR, “team-focused” CPR and “cardiocerebral resuscitation” (CCR).

When discussing CPR and the holy grail of evidence-based practice, there are a number of caveats to acknowledge.  Firstly, there have been a very limited number of prospective, randomized and controlled trials on CPR and resuscitation due to many inherent barriers to performing such a study – cost, the infrequency of out-of-hospital cardiac arrest (OHCA), and the difficulty and ethical concerns inherent in studying something which is thought to be efficacious (CPR) against something else which may not be.  Fortunately, there have been a number of trials conducted that can inform our practice, and large, curated resuscitation outcomes databases exist for retrospective studies.  In this article, we’ll discuss CPR, Rhode Island State EMS protocols, and the evidence for and against them.

LifePACT.jpg

In March of 2017, the Rhode Island Department of Health instituted new protocols requiring EMS providers to stay on the scene of an atraumatic cardiac arrest for up to 30-minutes, or until return of spontaneous circulation (ROSC) is achieved[i].  Pre-hospital medicine policies and protocols vary according to the region, state, resources, distance from definitive care, and culture.  When treating trauma patients, for example, EMS providers are instructed to transport as quickly as possible to a hospital.  Traditionally, EMS providers have also been taught to transport OHCA patients to hospitals quickly as well, so asking them to remain on-scene for up to 30-minutes is controversial.  According to the American Heart Association (AHA), approximately 355,000 people each year suffer an OHCA event (110 events per 100,000 population).  Studies vary, but the overall survival rate for OHCA is anywhere from 6-12%[ii],[iii] nationally.  Extrapolating these statistics to Rhode Island’s population of 1 million, we can estimate that approximately 1100 Rhode Islanders are having OHCA each year, or 3 people every day.  Clearly, OHCA is an important topic and is worth exerting considerable effort to improve outcomes.

Historically, we know that certain factors in OHCA have prognostic importance and are associated with better outcomes, including witnessed arrest, time to CPR and defibrillation, initial shockable rhythm (VT/VF), AED use, and patient ageiii,[iv].  Although there are a myriad of factors that play into treating OHCA patients – airway use, mechanical or manual CPR, ACLS drugs, etc., the idea behind emphasizing on-scene CPR is that it gives EMS agencies the opportunity to defibrillate as soon as possible, perform great CPR and increase a patient’s chance of ROSC by re-establishing myocardial perfusion, instead of focusing on patient packaging and transport.  In other words, the theory is that you can run a code in the field, in the ER, or in the back of an ambulance, but the sooner you run it well, the better odds a patient has of a good outcome.  Below, we’ll review some of the key concepts of high-quality CPR.

Continuous Chest Compressions

Chest compressions.JPG

Many simulation, animal and observational studies have been performed on all manner of aspects of CPR, including compression depth, recoil, and speed.  Recently, focus has been drawn to cardiocerebral resuscitation (CCR), or minimally interrupted, continuous CPR.  The concept behind this mode of CPR delivery is that of coronary perfusion pressure – that it takes time giving compressions to reach the threshold at which the heart has enough coronary blood flow to possibly begin beating again, and each pause in CPR resets the pressure to 0. In the 3-phase model of VF arrest, the first 5 minutes are the “electrical phase”, in which defibrillation can result in ROSC. After this is the “hemodynamic phase”, during which restoration of “adequate arterial pressure” by CPR can increase odds of ROSC.  Importantly, it can take up to 45 seconds to establish adequate arterial pressure.  Lastly is the “metabolic phase”, during which outcomes are poor[v],[vi].  According to this theory, the sooner patients get defibrillation and CPR, and the better the CPR is, the higher odds they have of ROSC.  To date, several registry-based studies seem to agree with this idea, and have demonstrated improved outcomes among both VF and non-VF arrests with high chest compression fraction (i.e., less CPR interruptions)[vii].  Assuming that continuous CPR, or high chest compression fraction is beneficial, it also follows that any interruptions during CPR can result in worse outcomes – for example, pauses around defibrillation, intubation and transport, and research has borne this out[viii].  It’s worth noting, however, that although many of these concepts have become resuscitation truths, not all research agrees.  In one of the few RCTs on CPR, published in the New England Journal in 2015, Nichol et al. compared continuous to interrupted chest compressions, and found no statistically-significant difference in favorable neurologic function at discharge, although the protocol compliance was low, and many variables were similar between both groups[ix].  Both groups, for example, had CPR fractions higher than typical, so both study groups may not be representative of the real world.

Passive Oxygenation and Delayed Intubation

Bag Valve Mask.jpg

One of the key exposures in the NEJM study by Nichol et al., was the mode of ventilation.  In comparing continuous to interrupted chest compressions, the “interruption” was providing rescue breaths in the traditional 30:2 ratio.  If we subscribe to the idea that it takes up to 45 seconds to develop enough coronary perfusion pressure that defibrillation might be successful, stopping CPR every 30 compressions begins to seem like a bad idea.  We also know that a provider’s focus on airway management can detract from compression quality.  One observational study found that pre-hospital providers caring for OHCA patients paused CPR a median of 109 seconds for airway placement[x].  Coupling this finding with other studies showing that CPR pause duration is associated with increased mortality[xi] leads us to consider forgetting about the airway completely (at least initially).  Other literature seems to support this idea.  McMullan et al published a paper in 2013 on data from the Cardiac Arrest Registry to Enhance Survival (CARES), evaluating different airway management techniques and their association with neurologically intact survival.  The authors found that of 10,691 OHCA patients, survival was highest among those who received neither endotracheal intubation nor supraglottic airways (OR of 1.31)[xii].  Although this appears damning for any types of airway management at face value, it’s worth noting that patients with the best outcome often will have no opportunity for airway management – in other words, they are shocked out of VF, then wake up!  More information is coming soon, with an RCT due to be published in 2020 comparing airway management methods prospectively.

CPR During Transport

Another significant factor in deciding whether to work a code on scene or transport rapidly is the quality of CPR possible.  On scene, with a team of prepared EMS personnel, it seems a reasonable assumption that CPR metrics would be superior.  Prior literature seems to support this conclusion, with a number of simulation studies demonstrating worse or more variable CPR metrics in patients during transport, such as compression depth and rate[xiii].  In a small study published by Olasveengen et al., non-traumatic OHCA patients had increased time without compressions during transport compared with when on scene (27% vs. 19%).  However, in one 2017 registry-based study in Canada, the proportion of OHCA patients receiving “high-quality” CPR, defined as depth >5cm, rate >100/min, and chest compression fraction of >0.7 was similar between on-scene and transported groups[xiv].  Even if EMS providers are able to provide high-quality CPR in the back of a moving ambulance, consideration must be made of the danger to EMS personnel, who are then required to stand and perform a physically demanding task in a moving vehicle.  The science is not completely clear on which method is superior – on-scene or in transport, though clearly these studies have implications for proponents of running on-scene codes.

Team-Focused CPR

Eager to implement these cutting-edge techniques, some EMS systems have published their results with high-quality, “pit-crew style” and “team-focused” CPR.  Stopyra published data from a prospectively collected pre and post-intervention cohort study in rural North Carolina.  Data was collected on OHCA from 1-year prior to the intervention and 1-year after the intervention implementation.  All OHCA of presumed cardiac etiology was included.  The intervention included training of all providers, including police and EMS.  They were instructed to fulfill a choreographed position based on the timing of their arrival to the code.  The first rescuer would begin CPR, the second would place defibrillation pads and insert a blind airway, the third would be the team leader.  After arrival of the third provider, parenteral access could be attempted.  Rescuers continued with resuscitation until ROSC or end tidal <10mm for 20 minutes.  They found that after protocol implementation, there was a significant increase in number of patients achieving ROSC (65.7% vs. 28.4%, p<0.001), though there was no statistically significant change in survival to discharge.  Some of the limitations of this study include the small n (105 total resuscitations), and the lack of ability to control for in-hospital care (with regards to the lack of difference in survival to discharge)[xv].

A second North Carolina was undertaken by Pearson et al, and published in Resuscitation, detailing OHCA outcomes before and after an intervention of “team-focused CPR”[xvi].  Researchers evaluated arrest characteristics of nearly 15,000 OHCA patients using CARES registry data.  EMS agencies self-reports compliance with “team-focused CPR”, which emphasized early defibrillation, high quality CPR, and airway management with BVM over advanced airways.  Authors used a logistic regression to control for arrest characteristics, such as CPR device used, witnessed or unwitnessed, race, comorbidities and hypothermia, and found that team-focused CPR had a better odds of good neurologic outcome as measured by cerebral performance category score (OR 1.5) compared with traditional CPR.

A similar effort was undertaken in Salt Lake City in 2011.  The results from SLC Fire Department’s “pit crew approach” were published in 2015 in the Journal of the American Heart Association.  This study had significantly larger numbers (737 attempted resuscitations), and was based in an urban department with 11 ALS units and 8 BLS units.   The intervention in SLC included use of defibrillator real-time feedback to rescuers, strong medical direction and QA of all OHCA calls, rhythm-filtering technology that allowed rescuers to see the rhythm during CPR prior to stopping for pulse-check, limited peri-shock pauses, and encouraged on-scene resuscitation (vs. early transport) to reduce interruptions inherent in transfer and transport.  Additionally, passive oxygen was applied via facemask for the first 6-8 minutes, and asynchronous BVM for all unwitnessed, pediatric and respiratory arrests. 

After the intervention, SLC Fire Department saw more field ROSC (44% vs. 30%, p<0.0001).  Among patients who survived to admission, there was more survival to discharge (50% vs. 37%, p=0.0005), and more patients with favorable neurologic function, defined as Cerebral Performance Category 1 or 2 (46% vs. 26%, p=0.0005), although there was no statistically significant change in survival to hospital admission.  Although these numbers are promising for high-quality CPR, several confounders are present, including improved medical control, and preferential triage of OHCA patients with ROSC to PCI-capable centers, which was not the practice in the pre-intervention period[xvii]. 

Rhode Island is among the first states to institute a protocol mandating 30-minutes of on-scene CPR. While some have demonstrated improved outcomes with the implementation of similar interventions, bundled together with CPR training, use of novel technology (such as real-time feedback, end-tidal CO2, and rhythm filtration programs), strong medical direction and QA, it remains to be seen whether a statewide intervention can lead to more ROSC in the field, and, more importantly, more neurologically intact survival to discharge.  Reviewing the resuscitation literature, we see the trend toward decreased initial advanced airway use, higher focus on continuous CPR and minimal interruptions, such as the peri-shock pause and, to delay transport of the patient until ROSC is achieved.  While local news reports have highlighted anecdotal success stories[xviii], the full impact of the Rhode Island intervention have yet to be described.

Faculty Reviewer: Nick Asselin, DO

References

[i] Rhode Island Statewide Emergency Medical Services Protocols.” Rhode Island Department of Health, p. 3.03a., health.ri.gov/publications/protocols/StatewideEmergencyMedicalServices.pdf.

[ii] Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., … Turner, M. B. (2015). Heart Disease and Stroke Statistics—2016 Update. Circulation, 133(4), e38–e360. https://doi.org/10.1161/cir.0000000000000350

[iii] Becker, L. B., Aufderheide, T. P., & Graham, R. (2015). Strategies to Improve Survival From Cardiac Arrest. JAMA, 314(3), 223. https://doi.org/10.1001/jama.2015.8454

[iv] Haukoos, J. S., Lewis, R. J., & Niemann, J. T. (2004). Prediction rules for estimating neurologic outcome following out-of-hospital cardiac arrest. Resuscitation, 63(2), 145–155. https://doi.org/10.1016/j.resuscitation.2004.04.014

[v] Weisfeldt, M. L., & Becker, L. B. (2002). Resuscitation After Cardiac Arrest. JAMA, 288(23), 3035. https://doi.org/10.1001/jama.288.23.3035

[vi] Berg, R. A., Sanders, A. B., Kern, K. B., Hilwig, R. W., Heidenreich, J. W., Porter, M. E., & Ewy, G. A. (2001). Adverse Hemodynamic Effects of Interrupting Chest Compressions for Rescue Breathing During Cardiopulmonary Resuscitation for Ventricular Fibrillation Cardiac Arrest. Circulation, 104(20), 2465–2470. https://doi.org/10.1161/hc4501.098926

[vii] Vaillancourt, C., Everson-Stewart, S., Christenson, J., Andrusiek, D., Powell, J., Nichol, G., … Stiell, I. G. (2011). The impact of increased chest compression fraction on return of spontaneous circulation for out-of-hospital cardiac arrest patients not in ventricular fibrillation. Resuscitation, 82(12), 1501–1507. https://doi.org/10.1016/j.resuscitation.2011.07.011

[viii] Cheskes, S., Schmicker, R. H., Christenson, J., Salcido, D. D., Rea, T., … Powell, J. (2011). Perishock Pause: An Independent Predictor of Survival From Out-of-Hospital Shockable Cardiac Arrest. Circulation, 124(1), 58–66. https://doi.org/10.1161/circulationaha.110.010736

[ix] Nichol, G., Leroux, B., Wang, H., Callaway, C. W., Sopko, G., Weisfeldt, M., … Ornato, J. P. (2015). Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 373(23), 2203–2214. https://doi.org/10.1056/nejmoa1509139

[x] Wang, H. E., Simeone, S. J., Weaver, M. D., & Callaway, C. W. (2009). Interruptions in Cardiopulmonary Resuscitation From Paramedic Endotracheal Intubation. Annals of Emergency Medicine, 54(5), 645–652.e1. https://doi.org/10.1016/j.annemergmed.2009.05.024

[xi] Brouwer, T. F., Walker, R. G., Chapman, F. W., & Koster, R. W. (2015). Association Between Chest Compression Interruptions and Clinical Outcomes of Ventricular Fibrillation Out-of-Hospital Cardiac ArrestCLINICAL PERSPECTIVE. Circulation, 132(11), 1030–1037. https://doi.org/10.1161/circulationaha.115.014016

[xii] McMullan, J., Gerecht, R., Bonomo, J., Robb, R., McNally, B., Donnelly, J., & Wang, H. E. (2014). Airway management and out-of-hospital cardiac arrest outcome in the CARES registry. Resuscitation, 85(5), 617–622. https://doi.org/10.1016/j.resuscitation.2014.02.007

[xiii] Roosa, J. R., Vadeboncoeur, T. F., Dommer, P. B., Panchal, A. R., Venuti, M., Smith, G., … Bobrow, B. J. (2013). CPR variability during ground ambulance transport of patients in cardiac arrest. Resuscitation, 84(5), 592–595. https://doi.org/10.1016/j.resuscitation.2012.07.042

[xiv] Cheskes, S., Byers, A., Zhan, C., Verbeek, P. R., Ko, D., Drennan, I. R., … Morrison, L. J. (2017). CPR quality during out-of-hospital cardiac arrest transport. Resuscitation, 114, 34–39. https://doi.org/10.1016/j.resuscitation.2017.02.016

[xv] Stopyra, J. P., Courage, C., Davis, C. A., Hiestand, B. C., Nelson, R. D., & Winslow, J. E. (2016). Impact of a “Team-focused CPR” Protocol on Out-of-hospital Cardiac Arrest Survival in a Rural EMS System. Critical Pathways in Cardiology, 15(3), 98–102. https://doi.org/10.1097/hpc.0000000000000080

[xvi] Pearson, D. A., Darrell Nelson, R., Monk, L., Tyson, C., Jollis, J. G., Granger, C. B., … Runyon, M. S. (2016). Comparison of team-focused CPR vs standard CPR in resuscitation from out-of-hospital cardiac arrest: Results from a statewide quality improvement initiative. Resuscitation, 105, 165–172. https://doi.org/10.1016/j.resuscitation.2016.04.008

[xvii] Hopkins, C. L., Burk, C., Moser, S., Meersman, J., Baldwin, C., & Youngquist, S. T. (2016). Implementation of Pit Crew Approach and Cardiopulmonary Resuscitation Metrics for Out‐of‐Hospital Cardiac Arrest Improves Patient Survival and Neurological Outcome. Journal of the American Heart Association, 5(1), e002892. https://doi.org/10.1161/jaha.115.002892

[xviii] http://wpri.com/2017/02/16/new-rule-cpr-for-30-minutes-before-taking-cardiac-arrest-victims-to-hospital/