Heparin-Induced Thrombocytopenia (HIT) Review

Heparin-induced thrombocytopenia (HIT) is a dangerous complication of heparin exposure. In HIT, the body creates an autoantibody against the complex of platelet factor 4 bound to heparin. The anti-PF4 autoantibodies can activate platelets and cause life- and limb-threatening clots in arteries and veins. In HIT, platelets generally fall by more than 50% five to ten [... read more]

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ICU Physiology in 1000 Words: IVC Collapse, Revisited – Part 2

Jon-Emile S. Kenny MD [@heart_lung] Please read part 1 and view the vodcast on IVC collapse prior to reading below; this post seeks to explain the interesting findings of Juhl-Olsen & colleagues [1] as well as provide a physiological rationale to Dr. Marik’s comments on my vodcast; there is a new explanatory animation at the [... read more]

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ICU Physiology in 1000 Words: IVC Collapse, Revisited – Part 1

Jon-Emile S. Kenny MD [@heart_lung] Three years ago I wanted to share my physiology website heart-lung.org; I needed a topic to stoke some interest, so I sent a brief essay to Matt here at pulmccm.org.  In it, I briefly described inspiratory IVC collapse and its relationship to volume status and volume responsiveness.  With this, the [... read more]

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