When it comes to the efficacy of glucocorticoid therapy for the treatment of septic shock, we have existed in a state of ambiguity, torn between the results of two contradictory RCTs. The first, the Annane et al trial published in JAMA in 2002, suggested a mortality benefit in favor of the corticosteroid group in the […]
Did this woman have ARDS? According to the Berlin Definition shown below, she had moderately severe ARDS while on conventional low tidal-volume ventilation (P/F ratio of 166). However, she didn't meet the definition of ARDS while she was APRV, a few hours earlier (P/F ratio 475). Her overall clinical course with prompt recovery and weaning off oxygen is inconsistent with the natural history of ARDS.