Dabigatran Reversal Agent – Idarucizumab

Thanks to Rob MacSweeney‘s fantastic Critical Care Reviews I learned of Idarucizumab, a monoclonal antibody fragment that binds the (pesky) anticoagulant dabigatran. Two industry-supported studies this week show rapid, complete reversal of anticoagulation in healthy volunteers(1) and patients who were either bleeding or undergoing procedures(2). The dose given to patients was 5g intravenously. An accompanying […]

Inhaled nitric oxide: a tool for all resuscitationists?

The use of inhaled nitric oxide is established in certain groups of patients: it improves oxygenation (but not survival) in patients with acute respiratory distress syndrome(1), and it is used in neonatology for management of persistent pulmonary hypertension of the newborn(2). But it can be applied in other resuscitation settings: in arrested or peri-arrest patients […]

Be Like That Guy – Dr John Hinds

  The critical care and #FOAMed community lost our friend Dr John Hinds a few days ago. We’re in the business of sudden death. As prehospital, emergency, acute medicine and intensive care clinicians, facing the reality of the tragic loss of a living person, loved by their friends and family, is our day job. This […]

Pre-SMACC mini RAGE

Currently the RAGE Podcast site is recovering from a cold, so here are the show notes for the pre-SMACC mini RAGE episode released June 2015. Here is the podcast And here are the references: SMACC Conference It’s a knockout GoodSAM GoodSAM App Oxygen therapy AVOID: Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction. HOT or […]

Post-arrest hypothermia in children did not improve outcome

Many clinicians extrapolate adult research findings to paediatric patients because there’s no alternative, and until now we’ve had to do that with post-cardiac arrest therapeutic hypothermia after paediatric cardiac arrest. However the THAPCA trial in the New England Journal of Medicine now provides child-specific data. It was a multicentre trial in the US which included […]