So here are , as many have requested, the details around the case I was tweeting about this week.
And here are some visuals:
i will add POCUS clips but these can be found on my twitter for now!
To all casebook owners:
Just in case of technical failure of the included DVD, here is a zip files of the cases:
thank you for reading!
Lawrence’s work on sepsis analysis is truly groundbreaking. To put this in perspective, one has to recognize that sepsis is an exceedingly heterogeneous disease that, once upon a time, and for good reasons, an arbitrary definition was formulated. This, however, does not reflect sepsis adequately, and needs to change with observational data, as this has tremendous implications in therapeutics research.
Lawrence’s efforts have resulted in data systems revealing a number of different patterns of sepsis, with clear differences in physiologic effects or responses. This may explain why so many failed therapies for sepsis have occurred. It is entirely plausible that some of these therapies may have effects in some of these phenotypes of sepsis but get lost in the statistical mix.
Love to answer any questions anyone may have, and Lawrence will certainly chime in on the discussion!