Abscesos hepáticos múltiples

El caso clínico: la paciente no tiene fiebre

J. es una paciente de 59 años, obesa, hipertensa, quien fue sometida a una inserción endoscópica de una prótesis biliar por una obstrucción del colédoco inicialmente atribuida a una neoplasia. Además tenía una cirrosis parcial hepática secundaria a una embolización intravascular previamente realizada.

La paciente consultó por dolor interescapular intenso y taquipnea iniciado una hora antes de su consulta al servicio de urgencias. Al examen físico la frecuencia respiratoria era de 44 rpm, la tensión arterial media era de 70 mmHg y la frecuencia cardíaca de 123 x’. Sin embargo no había fiebre (temperatura 36,5ºC) y la SpO2 era de 100%.

La tensión arterial comenzó a caer a niveles de 60/37 mmHg por lo que se inició oxígeno a FiO2 de 0,31 por máscara venturi, se cateterizaron 2 vías venosas para administración de soluciones y extracción de muestras para análisis sanguíneos y se practicó un TAC tóraco-abdominal ante una sospecha clínica de disección aórtica o un tromboembolismo pulmonar.

Rápidamente se administró 1000 ml de solución fisiológica (0,9%). El nivel de conciencia era de alerta y no había ruidos añadidos a la auscultación pulmonar. No obstante el abdomen era franca y exquisitamente doloroso en el hipocondrio derecho que era pétreo a la palpación superficial.

La TAC demostró la presencia de múltiples áreas hepáticas compatibles con abscesos por lo que inmediatamente se inició piperacilina/tazobactam EV y se activó la terapia guiada por objetivos para sepsis severa y shock séptico. Estas medidas incluyeron la administración de suero fisiológico a 30 ml/kg en reexpansión de volemia, la determinación de ácido láctico, la extracción de muestras para hemocultivo, continuar la administración de oxígeno, la monitorización invasiva mediante un catéter central con medición de PVC y ScO2, y ante la falta de respuesta a la reexpansión de volemia con cristaloides, una perfusión continua de noradrenalina fue iniciada con el objetivo de elevar la tensión arterial media por encima de 65 mmHg.

La paciente permanecía anúrica y no había ruidos intestinales.

El ácido láctico era de 8,4 mEq, había leucopenia de 3400 x mm3 e hipoglicemia. Además la actividad de protrombina (Quick) era de 9,8%, con hipoalbuminemia. La bilirrubina total era de 10 mg/dl con bilirrubina directa de 9 mg/dl.

Shock séptico y la cascada de la falla de órganos

Este es un caso claro de la catástrofe que significa la sepsis severa y el shock séptico, así como su curso cataclísmico y violento, tanto por el daño sistémico como por la velocidad de presentación. En apenas una hora o dos la cascada inflamatoria sistémica condujo a su vez a una cascada de falla de múltiples órganos en una paciente que además no estaba ni febril ni hipotérmica.

Muchos consideramos la fiebre como un signo cardinal en el diagnóstico de cualquier proceso infeccioso. Es evidente de este caso, con una infección documentada, que no siempre la fiebre es un hallazgo en la sepsis.

A pesar de la relativamente rápida actuación, el curso clínico puede ser también rápidamente deletéreo. Esto subraya una vez más la dependencia del tiempo en los resultados. Nunca se podrá enfatizar lo suficiente la necesidad de actuar a gran velocidad con sentido común en los pacientes con sepsis severa y shock séptico.

Cuando la sepsis se manifiesta clínicamente ya han ocurrido importantes alteraciones metabólicas a nivel molecular y celular, con trastornos de la microcirculación y disfunción orgánica que evoluciona continuamente. Sólo el tratamiento de sostén puede ser la opción, en tanto el sistema inmunitario contrarresta o potencia esta sucesión de eventos.

Continuará

Controversies in the Diagnosis of Subarachnoid Hemorrhage

Authors: Brit Long, MD (@long_brit, EM Chief Resident at SAUSHEC, USAF) and Alex Koyfman, MD (EM Attending Physician, UT Southwestern Medical Center / Parkland Memorial Hospital, @EMHighAK) // Edited by: Jennifer Robertson, MD

Background

The challenge of emergency medicine is to determine if a patient has a serious and/or deadly condition, even when he or she presents with a common chief complaint. Headache is a chief complaint that accounts for 2% of emergency department (ED) visits. Subarachnoid hemorrhage (SAH) is one condition that emergency physicians must diagnose, as it is serious and potentially deadly. Accounting for 1% of headaches, SAH is most commonly due to arterial aneurysm rupture1-3. The classic presentation of SAH is a sudden, severe headache. This warning sign occurs in up to 97% of cases.  Close to 85% of subarachnoid hemorrhages are non-traumatic. Approximately 80% of non-traumatic SAH are due to aneurysm rupture, while 10% are due to peri-mesencephalic hemorrhage.4-7 Risk factors for rupture include size and aneurysm location.11 One third to half of patients will experience a sentinel headache that precedes the subarachnoid hemorrhage. With 25% mortality within 2 hours of initial bleeding and 40% mortality at one week, missing this diagnosis can be deadly.16-19

How is this condition missed? 1) Failure to appreciate the clinical spectrum of SAH 2) Failure to obtain initial non-contrast head computed tomography (CT) or understand limitations in diagnosis, and 3) Failure to perform LP (lumbar puncture) and interpret results properly.20

The neurologically intact patient who presents to the ED with a headache presents several challenges. Traditionally, it has been recommended that SAH workup include a non-contrast head CT followed by LP if the initial CT is negative. 4,6,8 This recommendation has been questioned with novel imaging technology and recent literature. Multiple studies have evaluated different diagnostic strategies for subarachnoid hemorrhage including clinical decision rules (CDR), non-contrast head CT alone, combination head CT and LP, and non-contrast head CT with CT angiography (CTA).

Current Guidelines

The American College of Emergency Physicians (ACEP)  Clinical Policy on acute headache retains a Level B Recommendation that “lumbar puncture is the criterion standard for diagnosing subarachnoid hemorrhage because it may detect small amounts of xanthochromia or blood in the CSF that can be missed by CT.”23 The American Heart Association has a Level B Recommendation that states “acute diagnostic workup should include a non-contrast head CT, which, if non-diagnostic, should be followed by lumbar puncture.” Level C Recommendation is given for CTA consideration in the workup of SAH.24,25

Where does this leave emergency physicians, and what patient warrants evaluation for subarachnoid hemorrhage?

Clinical Decision Rules (CDR)

Clinical decision rules are often developed to decrease testing, but CDR’s can be challenging in rare diseases, as they require sensitivities approaching 100%. Three important SAH rules include the following rules below. Each rule had 100% sensitivities in their derivative studies.2

Rule 1

Investigate if ≥ 1 high-risk finding present:

  1. Age ≥ 40 years
  2. Neck pain or stiffness
  3. Witnessed loss of consciousness
  4. Onset during exertion

Rule 2

Investigate if ≥ 1 high-risk finding present:

  1. Age ≥ 45 years
  2. Arrival by ambulance
  3. Vomiting (≥ 1 episodes)
  4. Diastolic blood pressure ≥ 100 mmHg

Rule 3 

Investigate if ≥ 1 high-risk finding present:

  1. Age 45-55 years
  2. Neck pain or stiffness
  3. Arrival by ambulance
  4. Systolic blood pressure ≥ 160 mm Hg

Recently, a retrospective external validation study used each rule to measure their sensitivities.26,27 This retrospective study looked at patients with atraumatic headache and normal Glasgow Coma Scores (GCS). Sensitivities were 96% for Rule 1, 100% for Rule 2, and 89% for Rule 3. If vomiting was added, all were 100% sensitive.26,27 The original investigator completed an external validation and found sensitivities of 95-98%, and in order to increase sensitivity, the addition of thunderclap headache and limited neck flexion completed the Ottawa Subarachnoid Hemorrhage clinical decision rule, shown in Figure 1.26-28

Pic1

Figure 1 – Ottawa Subarachnoid Hemorrhage clinical decision ruleThe Ottawa Subarachnoid Hemorrhage (OSH) clinical decision rule demonstrated a sensitivity of 100% (with lower CI 97.2%) and 15.3% specificity. However, the OSH rule’s specificity and applicability to ED headache patients, as well as interobserver reliability, have been questioned. A second study found the rule would increase head CT/LP utilization.30 At this point, further external validation is needed but these rules do provide helpful red flags that clinicians can use when evaluating patients with headache.

Non-contrast Head CT

Much of the evaluation for SAH focuses on the non-contrast head CT, which has demonstrated increasing accuracy due to improved technology. Fifth generation scanners have sensitivities ranging from 93% to 100% depending on time from headache onset.31-35

The diagnostic accuracy of head CT is limited in several scenarios. CT scanner quality, the interpreter, and image artifacts may limit the study. Patients with hematocrit < 30% may have blood that appears isodense. Patients with normal exams and smaller hemorrhages may not demonstrate visible bleeding on the non-contrast CT. 36-38

New literature has evaluated the non-contrast head CT scan alone in evaluating for SAH within 6 hours of headache first occurrence. One prospective study evaluated 3000 patients and the sensitivity of non-contrast CT within the first 6 hours of symptoms.34,35 This study included patients with their worst ever atraumatic headache and the use of at least third generation CT scanners. Final diagnoses were all made by neuro-radiologists.

The results of this study showed non-contrast head CT to have a sensitivity and specificity of 100% for acute SAH within 6 hours of headache onset. However, after 6 hours of onset of symptoms, the sensitivity of non-contrast CT fell to 85.7%.  Similarly, a 2012 study found an initial non-contrast head CT within 6 hours of headache onset to have a sensitivity of 98.5% but excluding an atypical patient, the sensitivity of non-contrast head CT was 100%. 35 Thus, this study recommends that patients with atypical presentations and presentations later than 6 hours should still receive a lumbar puncture if initial head CT is negative, as non-contrast head CT has only a sensitivity of 90% in these situations.35

In conclusion, in a patient with a sudden, severe headache with a normal neurologic exam and symptoms occurring within the prior 6 hours, the literature does support eliminating the LP if the non-contrast head CT, read by a qualified neurologist, is negative. This places patients at less than 1% risk for SAH.

Lumbar Puncture and Cerebrospinal Fluid (CSF)

Many patients present after 6 hours of headache onset, where CT sensitivity decreases to 85.7%.34 LP after a non-diagnostic CT is recommended as per ACEP clinical policy. LP can also add useful clinical data and assist in differentiating among other diagnoses.23-25 Classic LP findings in SAH include an elevated opening pressure and elevated red blood cell (RBC) count that does not diminish from tube one to four with xanthochromia.40 There are, however, limitations in the interpretation of CSF results. First, is the question of CSF RBC clearing from tube 1 to tube 4.  Traumatic LP can occur in approximately 15% of studies and a clearance of zero RBC’s from tube 1 to tube 4 definitively diagnoses traumatic LP, but this is rare. Interpretation is often not as clear.41 Classically, there has been no absolute threshold for RBC cutoff or clearing in the diagnosis of SAH. One study found no patients with SAH with RBCs under 100 in tube 4. The study also found a 63% reduction in RBC from tube 1 to 4 to be the optimal threshold for clearance, but this has not been externally validated.42

LP does have several limitations, including inability to diagnosis pituitary apoplexy, cerebral venous sinus thrombosis, arterial dissection, and unruptured aneurysm. Traumatic lumbar puncture is, of course, a concern. The procedure is invasive, can be uncomfortable, and has known complications such as headache. The procedure can also be time-consuming and technically difficult in uncooperative and/or obese patients whose landmarks are difficult to find.

Xanthochromia

Xanthochromia is produced by hemoglobin product breakdown, resulting in a yellow tinge/color of the CSF. The presence of xanthochromia in the setting of SAH greatly reduces the chance of traumatic LP. Xanthochromia lasts for at least two weeks, but can take 2 to 12 hours to develop.43,44 Up to 20% of SAH patients who receive an LP within 6 hours of headache onset will have positive xanthochromia, but 100% will have its presence after 12 hours of headache occurrence.45,46

Xanthochromia is assessed by visual inspection (comparing the vial of CSF with a vial of water against a white background) or spectrophotometry. Studies have demonstrated wide variation in sensitivity of visual inspection, from 43% to 100%.41,45 Multi-wavelength spectrophotometry has recently been suggested as a superior means to detecting xanthrochromia.48 Despite the reported 100% sensitivity, it has poor specificity (29 to 75%).49,50 Additionally, less than 1% of laboratories in the U.S. contain a spectrophotometer, bringing into question this test’s applicability.44

Combination of CSF RBC and Xanthochromia

A recent study demonstrated that a combination of no xanthochromia with less than 2000 RBCs rules out SAH. This prospective cohort study enrolled patients with acute headache, and 3.5% of the cohort had SAH. Of the 1,739 patients who underwent LP (4141 total enrolled), 37% had blood or xanthochromia on LP. The vast majority were traumatic taps, as only 15 of 641 patients were actually diagnosed with SAH. The majority of false positives (74.3%) were with RBC counts of less than 100, with another 14.8% with counts between 100-1000 RBCs. A cutoff of 2000 RBCs had a sensitivity of 93%, but sensitivity was 100% with the addition of no xanthochromia.  However, this threshold was retrospectively derived from the studied cohort and this should be kept in mind when considering study results.51 Additionally, the sensitivity of xanthochromia alone was 47%, consistent with prior studies.

Computed tomography angiography (CTA)

CTA is an emerging noninvasive technology. The American Heart Association (AHA) clinical policy provides a Level C Recommendation for CTA to follow a non-diagnostic head CT.24 CTA can identify, localize, and characterize a culprit aneurysm, as well as diagnose other causes of headache. One other advantage of this strategy is the ability to perform the test directly after a non-contrast head CT.

However, the sensitivities of CTA range from 77% to 100% with specificities of 87% to 100%.52-58 A decrease in sensitivity occurs with aneurysms less than 4 mm.59,60 Proponents of using CTA following non-diagnostic initial non-contrast head CT cite improved patient comfort and improved sensitivity and specificity with the combination of non-contrast head CT and CTA. Negative non-contrast head CT and a negative CTA are likely indicative of a benign clinical course. However, opponents cite a rate of 2% to 5% of the population with asymptomatic aneurysms, leading to concerns of increased neurosurgical intervention if an aneurysm is discovered.11

The current diagnostic data on CTA comes from small cohort trials. These trials compare CTA to digital subtraction angiography (DSA) in patients already diagnosed with SAH.  In these studies, sensitivities range from 81% to 99%. Even the gold standard DSA can be negative in the setting of arteriospasm. Additionally, these studies do not provide data on the use of CTA for diagnosing SAH in the ED patient.

Assuming a 15% population prevalence of SAH, a recent mathematical analysis calculated the post-test probability of SAH following both negative non-contrast head CT and CTA. Ultimately, the study found a negative predictive value for CT/CTA of 99.4%. The model confidently states this is acceptable based on the number needed to complete a study comparing CT/CTA and CT/LP, where greater than 3,000 patients would be required. However, there are several negative factors with CTA. First, a negative head CT within 6 hours will more than likely be followed with a negative CTA. Second, CTA is an anatomic test that detects aneurysm, but it does not definitively state the cause of the headache. Finally, CTA also requires intravenous contrast, potentially causing allergic reaction or renal injury.61

Though the sensitivities of combination CT/CTA vary based on current data, this strategy can assist in several situations. CTA is beneficial in patients with high likelihood of SAH, obese patients, or patients where LP is not feasible (due to mental status, inability to cooperate, or patients who decline LP).  CTA will consistently reveal aneurysms larger than 3mm. A negative predictive value of 99.4% is useful in a clinical setting where LP may be difficult to complete, or the patient declines LP.

The Importance of Test threshold

One important aspect of medical care is test threshold, or what is an acceptable threshold for testing and potentially missing SAH? Explained in a different manner, at what threshold does further testing do more harm than good?62,63  A miss rate of 1% in many diseases is deemed acceptable. Once this threshold of 1% is crossed, further testing may cause harm to the patient rather than providing a benefit.62,63  For a patient with headache and concern for SAH, this means that if the initial test places the risk of missing SAH at less than 1%, LP will not assist the provider and patient but may cause further harm to the patient.

A sample calculation may help provide the probability of SAH with a negative head CT.62,64 With cerebral hemorrhage accounting for 6%-7% of headaches, and an assumed non-contrast head CT sensitivity of 90%, a negative head CT provides a 0.5% chance of missed SAH. This calculation is based on high-risk patient cohorts, where approximately 4/5 patients suffered worst-ever headache, 1/3 vomiting, and 5% had loss of consciousness. If a pretest probability of 50% is used for a high risk patient, then a negative head CT with 90% sensitivity provides a post-test probability of 10%. A low risk patient with a 1% pretest probability has a 0.1% post-test probability of missed bleed with a negative non-contrast head CT. Rapid onset of headache, worst of life headache, exertional headache, syncope with headache, vomiting, and neck stiffness are red flags associated with a higher pretest probability of SAH.64

Risk and the Shared Decision Making Model

This leads to the importance of risk stratification and using a shared decision model. Many EM physicians advocate that a physician does not rule out disease, but rather, risk stratifies. Thus, a negative head CT in a patient with headache within six hours does not rule out SAH, but risk stratifies the patient to less than 1% of having SAH. The patient and physician must work as a team, with the physician presenting the information and discussing the risks/benefits of further testing if the initial CT is negative. A negative LP and CT can rule out SAH, but LP is associated with patient pain, consumption of valuable time in the ED, and potential difficulty obtaining CSF results if the patient has poor body habitus and/or cooperation.61

Using a test threshold of less than 1% and head CT within 6 hours has literature support to be used in a shared decision model. For higher risk patients with red flags on history/exam or the patient presenting after 6 hours, discussion should be done with the patient regarding further testing.

What about current ACEP Clinical Policy? Dr. Edlow, one of the editors for the official policy, states that the EM practice should change in that the neurologically intact patient with a sudden, severe headache who undergoes a non-contrast head CT within 6 hours of headache onset no longer requires LP.65

Summary

Subarachnoid hemorrhage is a deadly disease and can present in a variety of ways, most commonly sudden, severe headache. Multiple diagnostic regimens exist, including non-contrast CT only, CT/LP, and CT/CTA. Many of these pathways have significant controversy. Within 6 hours of headache onset, a CT only approach does have literature support for risk stratifying patients to less than 1% risk of SAH. However, after 6 hours, the sensitivity of non-contrast head CT decreases. A test threshold of 1% does seem acceptable currently. Ultimately, a shared decision making model should be followed.

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Lumify Smartphone Powered Ultrasound System from Philips Debuts in U.S.

Lumify

Lumify-ultrasound
Philips is launching in the U.S. its new Lumify ultraportable smartphone or tablet powered ultrasound system. The system includes a couple of transducers (sold separately) that plug directly into the USB port of a compatible smartphone or tablet. The matching Lumify app running on the mobile device is then used to select and adjust various settings and to perform the exam.

The system lets the clinician select the preferred size and features of the mobile device, using its power to interact with the transducer and visualize the exam.

The Lumify works on a subscription model and through the app new transducers can be purchased, as well as various subscription types, training, and services, starting at $199 a month.

The app can be used to share exams with other clinicians, to make notations, and to email scans to others.

It comes with either the C5-2 broadband curved array transducer or the L12-4 broadband linear array transducer, at 5 to 2 MHz and 12 to 4 MHz extended operating frequency range, respectively.

 

Product page: Philips Lumify…

Flashback: Philips Lumify, an App-based Ultrasound System…

Source: Philips…

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