Subtle Dynamic T-waves, Followed by LAD Occlusion and Arrest

This case was written by Sam Ghali: (@EM_RESUS).  Thanks, Sam!


A 42-year-old lady presented to the ED with complaints of intermittent episodes of chest pain associated with shortness of breath for the last 2 days. This was her ECG (it is unclear if this was with or without pain):
Computerized ECG Read: “Normal sinus rhythm. Normal ECG.”
What do you think?


Sam's analysis
"There is sinus rhythm with a normal rate. QRS axis is shifted somewhat to the left. Intervals are normal. Overall this is a very quiet ECG. 

But if you look closely at the precordial T-waves you see a hint of terminal T-wave inversion in V2, and biphasic T-waves in Leads V3 and V4."

As above, it is unclear from the history whether the patient was experiencing chest pain at the time of this ECG, but these right precordial t-wave  findings were appreciated and the patient was treated with medical therapy and admitted to the hospital. 

Troponin T returned at less than 0.010 ng/L (normal)

A repeat ECG was performed 1.5 hours after the first (without pain):
 The precordial T-wave inversions appear to be resolving. A biphasic T-wave is only really well-appreciated in V3 now. 

2 hours later (3.5 hrs after the initial ECG) she develops severe, crushing chest pain. Another ECG is obtained:
 She suddenly occluded her LAD with a very large territory of viable myocardium at risk! 

Shortly after this ECG she suddenly went unresponsive and into V-Fib. CPR was initiated and she subsequently entered into V-Fib storm. After multiple shocks, 300 mg of Amiodarone, and 100 mg of Lidocaine she stabilized and was taken emergently to the cath lab. She was found to have a 100% occlusion of her Mid LAD just after the takeoff of D1 - which was reperfused and stented. Her 2nd troponin (drawn before her reocclusion/arrest) ended up coming back barely elevated at 0.015 ng/mL! (normal, less than 0.010 ng/mL)<0 .010="" font="" ml="" nbsp="" ng="">

She ended up doing fine and in the next few days was discharged home in good condition.

Smith comment:

T-wave inversion such as seen in the first ECG can be seen with active non-transmural ischemia.  We usually see this sort of T-wave inversion AFTER chest pain has resolved and, in that case, it is called "Wellens' syndrome," and implies that when the patient had pain the LAD was occluded, but that it spontaneously reperfused and resulted in "reperfusion" T-wave inversion. In such a case, the T-wave inversion would evolve into deeper and more symmetric (pattern B) T-wave inversion and troponins would be positive.  

But in this case, it is due to active ischemia, resolves with resolution of ischemia, and has little if any troponin elevation.

Here is another similar case:

Dynamic T-wave inversion (apparent Wellens' waves), all troponins negative: Unstable Angina

Sam's Learning Points:

1. Don’t trust the computerized ECG reading. The computer is not designed to pick up such subtle ECG findings as seen in this case . If this patient was discharged from the ED she very likely would have died. We must be the experts and pick up these life-saving ECG findings!

2. ACS can be a very dynamic process. For example, a coronary plaque ruptures: the vessel can undergo occlusion, spontaneous reperfusion, maybe reocclusion, again reperfusion, etc. At the time we are seeing the patient and reading their ECG remember that we are only seeing a snapshot of this process in time.

3. Unstable Angina still exists. There are some that overestimate the sensitivity of contemporary troponin assays and have come to believe that unstable angina no longer exists. This is very dangerous thinking. It is unclear whether high-sensitivity troponins will ultimately do away with unstable angina, but we are certainly not there yet. This lady nearly “ruled out with 2 sets” as her 3-hour troponin barely made the lab cut-off by 0.005 ng/mL and could have just as easily returned negative.

Smith comment

Had she not re-occluded and arrested, her troponin would not have gone above 0.010 ng/mL.  She would have been discharged.  Then re-occlusion and arrest might have happened at home.  Thus, unstable angina exists and can be deadly.

The ECG is still important, regardless of negative troponins.