Journal Club: Qualitative Research and Double Sequential Defibrillation

In this week’s edition of journal club we covered a paper that, through qualitative methods, assessed emergency physicians’ thoughts on opiate guidelines. As a group we have been speaking a lot about opiates and so we have elected not to cover the article in-depth in this review. We spent most of the night discussing qualitative methods in general. Below are some take aways for the next time you pick up a qualitative paper!

A great resource for critical appraisal of qualitative research is this BMJ article.

Journal Club May 2016

To download a pdf version of this article click here.

The staff article this week was an article looking at double sequential defibrillation and you can access it here. Though a simple case series it provided quite enthusiastic discussion. Next time you run into Adam or Colin ask them about what they think!

Look forward to seeing you at the next Journal Club!

5-MAPB: a novel psychoactive benzofuran


3.5 out of 5 stars

Acute Toxicity Associated With the Recreational Use of the Novel Psychoactive Benzofuran N-methyl-5-(2 aminopropyl)benzofuran. Sofer KE et al. Ann Emerg Med 2016 Apr 26 [Epub ahead of print]


5-MAPB is a psychoactive benzofuran with a structure and effects similar to those of MDMA (Ecstasy.) Although there has been scant investigation of its pharmacologic and toxic effects, animal studies indicate that it inhibits re-uptake of monoamines, especially serotonin.

This case report from Zurich Switzerland describes a patient with laboratory-confirmed exposure to 5-MAPB. He presented with signs and symptoms similar to those seen with MDMA or 5-APB: hypertension, tachycardia, diaphoresis, mydriasis, hyperthermia, agitation, hallucinations, seizures, and evidence of myocardial ischemia from coronary vasoconstriction. Treatment included supportive care, external cooling, sedation, and an alpha-blocker (urapidil.) The patient improved markedly within 14 hours of presentation.

Several years ago, a woman in Britain died after ingesting a mixture of 5-APB and 5-MAPB.

One small point: the paper states that the patient’s blood alcohol level was 0.48% (10.6 mmol/L.) This is an error. 0.48 gm% would be 480 mg/dL — six times the legal limit. 10.6 mmol/L is actually 48 mg/dL, which is clearly what the authors intended.


Related post:

Benzo Fury: prolonged paranoia and agitation after ingesting 6-APB