Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain?

Lateral Ankle Injuries in ChildrenAn 7-year-old girl presents to your Emergency Department (ED) with an ankle inversion injury from while performing gymnastics. Plain films of her ankle show no fracture. It has been a long-held presumption that skeletally immature children with fracture-negative radiographs should be immobilized with a cast given the concern for an occult Salter-Harris 1 fracture. “Children do not get sprains” is a common teaching point. But a recent 2016 JAMA Pediatrics article challenges that premise in a prospective cohort study of 135 pediatric patients.1 Can these injuries be managed more like a sprain, utilizing a removable ankle brace?

Objectives

The main objective of the study was to determine the incidence of true Salter-Harris 1 fracture of the distal fibula (SH1DF) in children ages 5-12 years using magnetic resonance imaging (MRI). Additionally the authors sought to compare the functional recovery of all patients with lateral ankle injuries (regardless of whether sprain or fracture) when treated similarly at discharge.

Methods

Children were included in the study if they were 5-12 years old, had an isolated lateral ankle injury, and clinically presumed to have SH1DF.

Exclusion criteria:

  • Injuries occurred over 3 days ago
  • Pre-existing musculoskeletal disorder or coagulopathy
  • Developmental delay
  • Ankle fracture in the past 3 months
  • Families with a language barrier

Patient care timeline:

  • T=0 days: In the initial ED visit, a functional assessment tool was filled out by families, the modified performance Activities Scale for Kids (ASKp), as a baseline of their functional status before the injury. All enrolled patients were treated with a removable air-stirrup brace and instructed to return to activities as tolerated.
  • T= 1 week: Patients underwent MRI.
  • T=1 month: Families again completed the ASKp and had follow-up with an orthopedic surgeon.
  • T=3 months: Families received a phone follow-up.

MRIs were reviewed by 3 pediatric radiologists, who were all blinded to the study findings. They categorized the injuries in:

  1. SH1DF
  2. Avulsion fracture
  3. Bone contusion
  4. Ligamentous injury

Outcome measures:

  • The primary outcome was the number of MRI-confirmed SH1DF.
  • Secondary outcome measures included the number of other injuries diagnosed on MRI (ligamentous injuries, avulsion fractures, or bone contusions), physical functioning as determined by the ASKp, and those who had full, painless weight-bearing capability and a return to normal activities at least “almost all the time”.

Results

135 children underwent MRI. This study had great follow-up in that 129 of those patients were seen at the 1-month follow-up, and 128 patients were seen at the 3-month follow-up. Of these 135 children, the following diagnoses were made:

  • SH1DF – 4
  • Ligamentous injury – 108
  • Avulsion fractures – 38
  • Bony contusions – 107
  • There was some overlap because some patients had multiple injuries (i.e., some patients had both ligamentous injury and fracture on MRI).

ASKp Scores

  • Baseline mean score for all patients = 92.3%
  • Mean score at 1 month follow-up = 83.4%

Full painless weight bearing ability

  • At 1 month follow-up = 72.1%
  • At 3 month follow-up = 96.1%

Return to normal activities “almost all the time”

  • At 1 month follow-up = 68.8%
  • At 3 month follow-up = 96.9%

Subgroup analysis: When they split the children into two groups, those with fracture on MRI and those without, there was no significant difference in the above measurements between the two groups.

Discussion

This study totes a multidisciplinary author group including pediatric emergency medicine physicians, radiologists, and orthopedic surgeons, all of whom play a role in the management of patients with these types of injuries. The authors report that the incidence of MRI-confirmed SH1DF is actually quite low and of the children with lateral ankle injuries in this study, nearly all of them reached full recovery within 3 months when treated with the same interventions regardless of fracture presence. They propose that with these results, practitioners can pursue a less-conservative approach to managing these patients and thus potentially avoid unnecessary interventions.

Limitations

The authors did not investigate long-term outcomes of growth arrest in these patients, which is a concern for patients with presumed growth plate injuries.The fibula is not a weight-bearing bone and thus the clinical significance of growth arrest may not be fully apparent in the short term period. Thus, these results may not be applicable to other Salter-Harris 1 fractures.

Ankle brace stirrup

Take home message

This study seems to serve as practice-changing evidence in emergency medicine. Children with lateral ankle injuries, open growth plates, and no fracture seen on x-ray, can be treated with a removable air-stirrup ankle brace for comfort and instructed to return to activity as tolerated. These patients can follow-up initially with their general pediatrician as opposed to an orthopedist.

 

1.
Boutis K, Plint A, Stimec J, et al. Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain? JAMA Pediatr. 2016;170(1):e154114.[PubMed]

Author information

Sarah Tomlinson, MD

Sarah Tomlinson, MD

Fellow
Pediatric Emergency Medicine
University of Michigan Health Systems

The post Radiograph-Negative Lateral Ankle Injuries in Children: Occult Growth Plate Fracture or Sprain? appeared first on ALiEM.

Agua para la limpieza de heridas

La imagen es de aquí
Después de todo, nuestras madres y nuestras abuelas eran muy sabias...¿Quién no recuerda aquellas heridas de guerra, casi siempre en las rodillas, que lucíamos de críos y que nos limpiaban con un buen refrotón de agua y jabón ? Y luego, la embadurnaban de "mercromina"...? Después de la consabida costra, se curaban solitas y asunto terminado.

Pues eso, que esta revisión de Cochrane nos dice que el agua pura, limpia y cristalina, es tan buena como el suero fisiológico para la limpieza de las heridas sean crónicas o agudas, en niños o en adultos...Naturalmente, hablo del agua del grifo de buena calidad, es decir la habitual en nuestro ámbito.
¿Cuánto nos gastaremos en suero salino de limpieza en nuestros centros...? ¿Cuántos pacientes pensarán que al limpiar la herida, banal, por la que acude con suero se justifica su presencia en el botiquín...? ¿No deberíamos cambiar la práctica y aprovechar para hacer un poquito de educación sanitaria: "la próxima vez, no es preciso que acuda; limpie su herida en casa con agua y manténgala seca y se curará solita..."

Lo de la "mercromina" lo dejo para otra vez.

The ED Approach To The Comatose Patient

 

Author: Paul Trinquero, MD (EM Resident Physician, PGY-2, NUEM) // Edited by: Laura Alkawham, MD // Expert Commentary: Abra Fant, MD

Citation: [Peer-Reviewed, Web Publication] Trinquero P, Alkawham L  (2016, August 30). The ED Approach To The Comatose Patient [NUEM Blog. Expert Commentary By Fant A]. Retrieved from http://www.nuemblog.com/blog/the-comatose-patient/


Relevance

Coma is a fairly common problem encountered in emergency departments (EDs) across the country. Approximately 3% of all ED patients arrive in some sort of altered mental state. The differential diagnosis is broad, but initial evaluation should center on treating any reversible causes and attempting to differentiate a structural brain lesion from a more systemic toxicity. Approximately 85% of altered mental status cases are caused by metabolic or systemic derangements. Structural lesions cause 15% of cases. 


Top three out-of-hospital causes of AMS

Screen Shot 2016-03-31 at 4.31.35 PM.png

 

  • Intoxication

  • Complications of diabetes (hypo- or hyperglycemia)

  • Traumatic injury


Introduction

Consciousness is the combination of arousal and cognition. Arousal is synonymous with awareness, both of self and surroundings. The primary neuroanatomic structure responsible for arousal is the ascending reticular activating system (RAS), located in the brainstem. Cognition is the combination of orientation, judgment, and memory. The structures responsible for these crucial components of cognition are spread throughout the cerebral cortices. 

Therefore, in order to be awake, aware of our surroundings, and fully oriented, we require intact cerebral cortices and an intact RAS. A fully comatose state implies dysfunction either in both cerebral cortices or dysfunction of the brainstem where the ascending RAS fibers originate. Importantly, localized, unilateral lesions in the cortex, such as a cerebrovascular accident (CVA), tend not to induce a coma, unless there is massive herniation. Localized lesions to the brainstem however can impair the RAS and lead to altered mental status (AMS) or coma.

The overall goal of the examination in a comatose patient is to identify key clinical findings that will help narrow your differential diagnosis of the patient's comatose state. In addition, it is useful to accurately document the patient’s current condition so that subsequent exams can accurately describe any dynamic changes in clinical status.

One way to break down the differential diagnosis of a comatose patient (courtesy of LITFL) is to categorize as follows:

  1. Coma with focal or lateralizing signs 
    1. CVA (ischemic or hemorrhagic)
    2. Trauma
    3. Space occupying lesion (tumor or infectious)
  2. Coma with meningismus
    1. Meningoencephalitis
    2. Subarachnoid hemorrhage (SAH)
  3. Coma with neither localizing signs nor meningismus (TOMES)
  Screen Shot 2016-03-31 at 4.28.46 PM.png  

With that goal in mind, below you will find an interactive diagram of a comatose patient which highlights key components of the examination and initial evaluation to help you narrow your differential diagnosis. Click the links to open up text boxes with further descriptions.


Examination of the Comatose Patient

General

The GCS (although developed for trauma) can be used to quantify level of consciousness. This is especially helpful to track changes during serial exams. Descriptive words also help. It is best to think of consciousness on a spectrum extending from normal to coma. Mild disturbances in awareness such as confusion and delirium are on one end of the spectrum. As awareness decreases the patient becomes lethargic (extremely drowsy and repeatedly requiring awakening with moderate stimulation), which can progress to obtundation (in addition to extreme drowsiness, also has slowed responses to stimuli). Stupor describes a patient that will only arouse to vigorous and repeated stimuli and immediately lapse back into unconsciousness as soon as undisturbed. Coma is a state of unarousable unresponsiveness, the far end of the spectrum. 

Age

The age of a patient can provide clues towards the most likely etiology:

  • Infant: infection, metabolic (possibly inborn error or metabolism), trauma/abuse

  • Child: toxic ingestion

  • Young adult: recreational drugs, alcohol, trauma, toxic ingestion

  • Elderly: medication changes, over the counter medications, infection, environmental, stroke, trauma 

 

Vitals

  • Hypoxia should be addressed immediately whether this is via oxygen supplementation or endotracheal intubation.
  • Hypotension can reflect circulatory failure from sepsis, hypovolemia or cardiac failure, specific drugs or Addison's disease.
  • Extreme hypertension could suggest posterior reversible encephalopathy syndrome (PRES) or hypertensive hemorrhage.
  • Both bradycardia and tachycardia can be the result of specific toxic or metabolic etiologies (bradycardia and hypotension, think beta-blocker/calcium channel blocker overdose). Bradycardia may also be the result of increased ICP as part of the Cushing response.
  • Be sure to obtain a rectal temperature. Hyperthermia usually signifies infection but one should also consider heat stroke or anticholinergic intoxication. Hypothermia may be accidental or secondary to less common etiologies as adrenal failure, hypothyroidism, sepsis, or drug/alcohol intoxication.
  • Respiratory pattern to be addressed in later section.

Fingerstick glucose

Hypoglycemia is one of the most common causes of undifferentiated coma presenting to the ED and is easily reversible prior to initiation of further invasive workup. Significant hyperglycemia could prompt additional workup to evaluate for diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS). 

EKG

Be sure to look for abnormalities that could point towards electrolyte imbalances or arrhythmias as well as characteristics of specific toxidromes. Prolonged QRS, consider tricyclic overdose. Sagging ST depression may represent digoxin toxicity. 

 

 

Exam

The physical exam in the comatose patient should be focused on identifying reversible causes of their depressed mental state as well as assisting with appropriate laboratory and imaging work up. 

The comatose patient should be completely exposed to assess for any clues that may assist with the etiology of their comatose state. 

The comatose patient should be completely exposed to assess for any clues that may assist with the etiology of their comatose state. 

Key Examination Findings

    + Evaluate for Head Trauma

• Raccoon eyes: bilateral periorbital ecchymosis, which could potentially be the result of a tear in the venous sinus leaking blood into the cranial sinuses and seeping into the soft tissue around the eyes

• Battle’s sign: mastoid ecchymosis, which could represent rupture of the posterior auricular artery

• Hemotympanum: blood in the middle ear

• CSF rhinorrhea or otorrhea: represent a traumatic tear in the meninges with subsequent leakage of CSF

    + Eyes

• Unilateral pupillary dilation: assumed to be caused by oculomotor nerve compression from ipsilateral uncal herniation until proven otherwise.

• Bilateral dilated pupils that are nonreactive: a sign of extensive midbrain injury, central herniation, or toxidrome (TCA, anticholinergic, amphetamines, carbamazepine)

• Bilateral miosis: could potentially represent sedative intoxication (opioids, benzos, barbituates, clonidine, GHB), pontine lesions, or cholinergic toxicity (organophosphate)

• Fixed, midsized: concerning for midbrain lesion or impending hernation

• Eye deviation: Ongoing deviation of the eyes may suggest underlying seizure activity that may not be otherwise clinically apparent

• Oculocephalic reflex (dolls eyes reflex): If intact, this reflex demonstrates functionality of a vast majority of the brainstem, making a brainstem lesion very unlikely to be the etiology of the patient’s altered mental status.

    + Mouth

• Lateral tongue laceration: Seizure

• Dry mucous membranes: Anticholinergic toxicity or severe dehydration

• Excessive salivation: Cholinergic toxicity

    + Neck

• Nuchal rigidity may be the only sign of meningitis on exam

    + Respiratory Pattern

• Cheyne-Stokes respiration: crescendo-decrescendo pattern of increasingly deep breathing followed by a decrease all the way to a period of apnea. Indicative of unstable feedback to the respiratory center

• Kussmaul respirations: deep, rapid breathing. A respiratory compensation for metabolic acidosis

• Central hyperventilation or apnea: implies brainstem dysfunction which can result from sedative, alcohol intoxication, trauma or vascular accident

    + Cardiovascular

• Bradycardia: beta-blocker/calcium channel blocker/digoxin overdose or Cushing response

• Tachycardia: Toxic, metabolic or primary cardiac disorder

    + Motor

• It is important to attempt to elicit extremity movements & reflexes assessing for asymmetries which could imply a lesion affecting the opposite cerebral hemisphere or upper brainstem

• Rigidity could be due to intrinsic muscle problems such as rhabdomyolysis or could be part of a toxidrome such as serotonin syndrome or neuroleptic malignant syndrome (NMS)

• Hyperreflexia is classically seen in serotonin syndrome and sympathomimetic intoxication

• Abnormal posturing whether decorticate or decerebrate can indicate injury extending into brainstem

    + Skin

• Wet skin along with elevated heart rate, blood pressure and respiratory rate suggests toxic ingestion of sympathomimetic, serotonin syndrome, NMS or cholinergic toxicity

• Dry skin along with elevated heart rate, blood pressure and respiratory rate suggests anticholinergic toxicity

• Antecubital needle marks: IV drug use

• Pale skin: Anemia or hemorrhage

• Generalized cyanosis: Hypoxemia (consider heroin overdose)

• Grayish-blue cyanosis: Methemoglobin intoxication

• Cherry-red skin: Carbon monoxide poisoning

• Jaundice: Hepatic dysfunction or hemolytic anemia

• Petechiae: DIC, TTP, drugs

• Ecchymosis: Trauma, corticosteroid use, abnormal coagulation from liver disease or anticoagulants

• Vesicular rash: Consider herpes or VZV encephalitis

• Petechial-purpuric rash: Meningococcemia or other bacterial sepsis, endocarditis, purpura fulminans, rocky mountain spotted fever

• Macular-papular rash: Typhus, candida, cryptococcus, toxoplasmosis, subacute bacterial endocarditis, staphylococcal toxic shock, typhoid, leptospirosis, pseudomonal sepsis, immunological disorders

• Ecthyma gangrenosum: Necrotic eschar often seen in the anogenital or axillary area in Pseudomonal sepsis

• Splinter hemorrhages: Linear hemorrhages under the nail, seen in subacute bacterial endocarditis, anemia, leukemia, and sepsis

Accurately documenting GCS early will help you to follow the patient's clinical course for improvement or deterioration.

Accurately documenting GCS early will help you to follow the patient's clinical course for improvement or deterioration.

Labs

  • Chemistry panel: to evaluate for anion gap acidosis, profound renal dysfunction or uremia, and rule out severe electrolyte disturbances such as hypercalcemia that can cause coma
  • CBC: to screen for severe anemia and, although less useful, to screen for leukocytosis as a nonspecific marker of infection or stress. Low platelets may increase suspicion for ICH or DIC
  • Coagulation panels: to evaluate for supratherapeutic anticoagulation or evidence of liver dysfunction or bleeding dyscrasias
  • ABG: to evaluate for severe hypoxia or hypercapnia
  • TSH: can be considered to rule out myxedema coma or thyroid storm
  • Urinalysis: to evaluate for infection as a common cause of coma in the elderly. Specific gravity can also be useful for helping to determine volume status
  • CSF studies: should be considered in any patient where there is suspicion for meningitis or high suspicion remains for SAH after a negative CT brain
  • Toxic screen: ASA level, APAP level, ETOH level, methanol/ethylene glycol (Consider if elevated anion gap acidosis present)

Imaging

  • CXR: a quick and simple study to screen for obvious lung pathology such as pneumonia, effusions, or ARDS
  • CT brain (noncontrast): the mainstay of ED imaging for AMS/coma because of its availability and efficiency.  Although evaluation of the posterior fossa is often limited due to artifact from the skull base, this test can reveal the vast majority of ICH that are large enough to cause a coma
  • CT angiography/venography: if available can help to diagnose vertebral or basilar artery occlusion, intracerebral aneurysm, veneous sinus thrombosis, or AV malformation

Always Consider Tox

Beyond looking for clinical toxidromes or key exam findings, be sure to track down a list of the patient’s medications and pay close attention to any new additions or dosage changes. Obtaining further information from EMS, family or friends may be critical in making the diagnosis.


Summary

  • Consciousness is the combination of arousal and cognition. Arousal is synonymous with awareness, both of self and surroundings. Cognition is the combination of orientation, judgment, and memory.
  • In order to be awake, aware of our surroundings, and fully oriented, we require intact cerebral cortices and an intact RAS. A fully comatose state implies dysfunction either in both cerebral cortices or dysfunction of the brainstem where the ascending RAS fibers originate.
  • The overarching goal of the physical examination of a comatose patient is first to treat any reversible causes and then to attempt to differentiate a structural lesion causing localizing neurologic findings from a more systemic disturbance.
  • A careful examination and strategic laboratory testing as proposed above can help to guide further testing and management by narrowing down the differential diagnosis
  • Always consider toxic ingestion on the differential diagnosis and strive to obtain collateral information to assist your work up

Expert Commentary

Thank you for your succinct review of a common, and often complex, chief complaint in the ED.  The comatose patient, by definition, cannot provide much context or history to his or her condition, so the clinician must rely on examination skills and some of the heuristics mentioned in the post.

As with all critical patients, the assessment should begin with the ABCs: airway, breathing and circulation, but should also add the D of dextrose.

The point of care glucose is an incredibly powerful tool in the comatose patient and should be utilized as soon as other life threats have been addressed. Additionally, any comatose patient without a clear history of being found in bed or some other obvious overture to their current condition should be considered to have trauma. Perform a full secondary survey as soon as possible. This will help identify not just any occult trauma the patient may have sustained but also help evaluate skin parameters and tone. This is also a good time to look for transdermal medication patches that may be contributing to the patient’s mental status. While the patient is rolled, take the opportunity to obtain a central temperature – this can differ greatly from a surface temperature.

Characterizing causes of coma by age can be useful, however remember that infection and trauma can present at any age, and toxic ingestions can also present across the spectrum either as intentional or unintentional. This is where a thorough exam and choice laboratory and imaging tests can help. The list of blood tests in the post is quite extensive, although I would argue that one should recognize thyroid storm by virtue of exam rather than requiring a TSH level.  An alcohol level can be helpful – it may justify your suspicion that the coma is simply due to profound intoxication – or it may remove that option from the table and require that you continue your investigations. 

Just a few other pearls:

  • Kussmaul breathing is NEVER normal. This should set all your alarms off. Worry about acidosis, either from infection or DKA (most commonly). However, if the patient smells of alcohol consider both AKA and toxic alcohol ingestion.
  • GHB can present with profound coma. Often you can gain some insight from EMS who will report that the patient was found in a party setting. In these situations, provide supportive care – the patient may metabolize and wake up even during the course of your shift.
  • Hyperthermia can cause altered mental status, but remember to look for the cause of the hyperthermia. Is this exertional? Is this an elderly person who was relatively immobilized by another condition? Was this person exposed due to immobility from trauma? Is this a toxicologic cause (eg serotonin syndrome, NDMA, anticholinergic ingestion)?

While diagnosing the comatose patient can be a difficult task, relying on physical exam skills and a thorough approach can help direct initial plans of care. Keep an open mind, avoid early diagnostic closure, and always check that glucose!

 

Abra Fant , MD, MS

Instructor; Department of Emergency Medicine, Northwestern University, Feinberg School of Medicine


Other Posts You May Enjoy


References

  • Adams, J., Bassin, B., Cooke, J., Barsan, W. (2013). Altered Mental Status and Coma. Emergency Medicine: Clinical Essentials. Philadelphia, Pa: Elsevier/ Saunders. Pages 811-817.
  • Nickson, C. Toxidrome Challenge. Life in the Fast Lane. http://lifeinthefastlane.com/toxicology-conundrum-025/
  • Nickson, C. Examination of the unconscious patient. (2015) Life in the Fast Lane. http://lifeinthefastlane.com/ccc/examination-unconscious-patient/
  • Skaff, P. Neurologic examination of the unconscious patient. (Dec 2010). Retrieved from: https://www.youtube.com/watch?v=CUaEwgfKOEc
  • Stevens, R. D., & Bhardwaj, A. (2006). Approach to the comatose patient. Critical care medicine, 34(1), 31-41.
  • Tindall SC. Level of Consciousness. In: Walker HK, Hall WD, Hurst JW. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 57. Available from: http://www.ncbi.nlm.nih.gov/books/NBK380/

#FOAMed of the Week: Approach to Paeds EM via @Damian_Roland and @EM3FOAMed

This is a great PEM induction video from the #EM3 team in the East Midlands (inc Damian Roland). Its got some great clips of clinical signs you will need to recognise in unwell children. 

Some of the pattern recognition we learn in adult practice doesn't quite work as well in children. Using a structured approach if it isn't immediately apparent whats going on can help you pick your way around some of the common pitfalls. They suggest the nice traffic light system in this video. 

For more excellent PEM hints and tips check out links like this: 

http://dontforgetthebubbles.com/paediatric-emergency-medicine-monthly-foamed-review/