Tox Tunes #73: Hush Hush (Pistol Annies)

http://www.youtube.com/watch?v=OkvjhWirED8

In a recent post titled “Hashville Skyline”, Slate describes the way that references to marijuana has infiltrated into country music tracks over the last decade or so. In this single, from the Pistol Annies‘ new album Annie Upone of the singers describes how she relieved the tension surrounding a drunken family Christmas dinner by sneaking out for some weed:

So I snuck out behind the red barn
And I took myself a toke
Since everybody here hates everybody here
Hell I might as well be the joke

In future editions of “Tox Tunes”, we’ll visit some of the other country songs in which pot makes an appearance.

 

TCA overdose, toxic beer, and allegations of a mayor on crack: Weekly Web Review in Toxicology

Tricyclic Antidepressant Overdose – Over at EMCrit Blog, Scott Weingart has posted a superb podcast discussing the presentation and treatment of TCA overdose. In severe cases not responding to standard therapy, lidocaine, lipid rescue, or ECMO may be indicated. Gastrointestinal lavage — I’m not so sure. Both the podcast and the show notes are well worth your attention.

Was Toronto mayor Rob Ford caught on film smoking crack? 

http://www.youtube.com/watch?v=IaOerRnp4KU

Two journalists from the Toronto Star report that they have seen a video apparently showing mayor Rob Ford smoking from a crack pipe. The mayor has issued what appear to be non-denial denialsNew York Magazine has chronicled 20 instances of bizarre behavior exhibited by the mayor, at least several seeming drug related. And in an hilarious featureSlate challenges the reader to identify whether each of 20 different quotations were uttered by Mayor Rob Ford of Toronto or Mayor Diamond Joe Quimby of the Simpsons’ hometown Springfield.

Toxic Beer – A Florida man is suing a Dallas-area Red Lobster for caustic injuries apparently sustained after drinking a draft beer ordered at the restaurant.  The Dallas Observer reports that Justin Grogg, in town from Florida on a business trip, developed severe pharyngeal and gastrointestinal pain immediately after downing the beer. Gregg’s lawsuit claims that the restaurant had cleaned in beer’s keg and tubing with potassium hydroxide earlier that day, but neglected to rinse system adequately. The suit is seeking compensation for mental and physical pain, as well as medical expenses.

 

JC: Does Magnesium work in asthma? St.Emlyn’s

St Emlyns - Meducation in Virchester #FOAM

wikimedia

wikimedia

This is a roller coaster journey  for me. Many years ago Virchester ED was one of the first hospitals to start using Magnesium for the treatment of acute severe asthma. This prompted great concern amongst some in-hospital colleagues….., and when we started using it in kids OMG (as my daughter might say) it felt as though we were trying to kill the kids!

Time goes on.

These days the first question out of the admitting teams mouths is “Have you given Magnesium yet?” and I’ve even seen MgSO4 administered to mild/moderate asthmatics in preference to Salbutamol for patients who don’t like nebulisers. I sigh and take the opportunity for learning delivery (that’s me to them…..).

Anyway, the evidence for Magnesium in asthma was never really that fantastic. Systematic reviews showed an effect but it was not quite as dramatic as some people now think. There is a nice review here in theEMJ from the Sheffield team, which informed the latest RCT pre-published in the Lancet this month.

3MG trial copy

The 3MG trial led by Steve Goodacre in Sheffield aimed to determine if nebulised Mg and IV Mg are effective in the management of acute severe asthma.

Who was studied?

The authors wanted to look at acute severe asthma. In this study that meant adult patients with acute asthma, with either a peak expiratory flow rate of <50% of best or predicted, respiratory rate >25 breaths per min, heart rate >110 beats per min, or inability to complete sentences in one breath. Interestingly they excluded patients with life threatening features, interesting as that’s a group that give me great anxiety. Arguably the life threatening patients are the ones where I tend to chuck the kitchen sink of therapies at (Ed – bit more technical than that I’m sure, but I know what you mean).

There were three groups in the study. All patients got an IV and a nebuliser, but the groups received.

  • IV MgSO4 and placebo neb
  • IV placebo and MgSO4 neb
  • IV placebo and placebo neb

So, a pretty good design with a placebo arm. I like this as the evidence was on the weak side from past trials and systematic reviews.

Principal outcomes were admission to hospital and breathlessness at 2 hours.

The main results

Interesting. Read the full paper, but in essence the effect of MgSO4 in these patients appears minimal. Nebulised MgSO4 appears to have no effect at all. IV has a minimal effect on admission rates, but does not affect the patient centred outcome of breathlessness.

They also look at a bunch of other outcomes, complications, side effects and again the benefit of MgSO4 is absent in nebulised and minimal for IV. This is a very different picture to the perception of colleagues in my practice and I think this will come as a shock.

Any concerns with methodology?

Not especially. This is a good pragmatic trial. Care in all groups was performed at the discretion of the treating teams according to British Thoracic Society guidelines, and arguably that might vary, but I like this. Pragmatic trials probably indicate the difference that we will get in practice and are a bit more ‘real world’ than some highly controlled studies. This is a good paper for teaching about such trials (I’m keeping it on my list of good trials for critical appraisal)

What do the results mean for me and my clinical practice?

Well, the rollercoaster plummets again. Is MgSO4 down and out? Well probably…

  • Nebulised MgSO4 is almost certainly not worth it in adults.
  • Nebulised MgSO4 works in kids (the MAGNETIC trial results)
  • We don’t know about patients with life threatening asthma – I’ll probably still keep giving it.
  • I am going to have some interesting conversations with the admitting teams over the next few months. Perhaps in a few years their first statement will be….‘You haven’t given Magnesium have you????’

What about you?

  1. Are you going to stop using IV Magnesium on the basis of this?
  2. Are you going to stop using Nebulised Magnesium in adults?
  3. What about patients with life threatening features?

I’d love to hear your thoughts.

Simon Carley

 

Conflict of interest – I know & respect all the authors. I don’t think it colours my judgement, but just so you know :-)

 

The post JC: Does Magnesium work in asthma? St.Emlyn’s appeared first on St Emlyns.

Tiny Tips – Altered Mental Status

Altered mental status is a frequent presentation with a very broad differential. Having a solid approach helps provide structure to the workup of a difficult group of patients.

IS IT MEAT is a common mnemonic for this presentation and the best one that I have come across (thanks to Nadim Lalani from ermentor.com for teaching it to me). Not only do the letters have fairly intuitive meaning, but they also provide a structural approach with IS IT representing intracranial causes while MEAT represents extracranial causes.

IS IT MEAT mnemonic

Medical students, the next time an attending asks you for a differential of altered mental status, bust out something like this:

Altered mental status can be caused by intracranial and extracranial pathology. Intracranial causes can include… while extracranial causes can include… Based on this patient’s presentation, I think x or y is the most likely but can’t forget about a, b or c because missing them could lead to a disastrous outcome.

And they’ll think you’re all clever and organized and stuff.

While it’s a very good acronym, there are unfortunately a few things it doesn’t mention that are important to consider. Specifically, hypertensive encephalopathy and post-ictal state do not have a place (although they can lead to or be the result of some of the other things on the list).

This memory device, as well as the rest of the Tiny Tips, have been made into flashcards that can be downloaded and used as outlined on the Boring Cards page. Check it out!

Author information

Brent Thoma
Emergency Medicine Resident at University of Saskatchewan
A Canadian that loves emergency medicine, simulation, education, mentorship, leadership, quality improvement, writing, parliamentary procedure, Star Wars, Dodgeball, his dog and a few people.

The post Tiny Tips – Altered Mental Status appeared first on BoringEM and was written by .

Webucation 19/5

Been away for a few weeks on a course. The web has been active though and here's more than a few good articles to ponder over.

  • How-marriage-works-in-medicine - interesting read for those in and around wedlock and even more interesting for those not "locked"
  • Ringer's ain't great...again. - not as much volume expansion as you once thought
  • FOOSH again - excellent revision on a not so common wrist injury from Emergucate
  • PTX aspiration - great video by NEJM on needle aspiration of pneumothorax of you have not seen one before.
  • Don't ignore naughty parts! - the trauma pro talks about not ignoring stuff down below
  • Macrolides and CCBs - do they interact and cause shock?
  • LUL collapse - we agree that its probably the hardest collapse to see on CXR
  • Microbiology pearls - truly one of the best write-ups we have seen recently. What every hospital doc should know about those pesky microbes and what really happens. We cannot recommend this link enough.


Infertility: GP management with Dr Penny Wilson

Infertility (or sub fertility – to be PC) is a common problem for which women (and men / couples) presen tto GPs.  It can be a really tricky area trying to work out the how, why and what.  I think we tend to do a lot of tests where often a careful history and rational approach to the patient and their partner can be really useful.

I enlisted Dr Penny Wilson once again to chat (teach me) all about infertility in the GP office.  DIRECT DOWNLOAD here

Enjoy
Casey

Peritonsillar Abscess About a month ago, I posted a video with…



Peritonsillar Abscess

About a month ago, I posted a video with the following history and questions.  Let’s take a look at the answers: 

A 23 year old male presents to the ED with 4 days of sore throat, getting much worse over the last 24 hours.  You note that he has a muffled sounding voice.  On exam, he has trismus, uvular deviation, L sided tonsillar asymmetry, and could seriously use a breath mint.  Your attending decides to perform an intraoral ultrasound to evaluate the patient, and you see the above image.  

1. What do you see?

As correctly pointed out by a few, what you were looking at was a peritonsillar abscess, noted as the anechoic circular area adjacent to the tonsillar tissue.  This is the most common deep space infection of the head and neck.  

2.  What is the next step in management?

First, you want to make your patient comfortable.  Start with some pain medicine.  Steroids have been shown in some studies to potentially decrease hospitalization time,  and perhaps help with symptom relief, but there is question as to the risk-benefit profile.  Use your clinical discretion.  Perform intramural US to confirm the presence of a PTA and distinguish from cellulitis.  Once comfortable, you may proceed with needle aspiration (no significant evidence that aspiration or ID are different in terms of outcomes).  I prefer ultrasound guidance.  More on that in the podcast.  

3.  Should you start antibiotics or not?

Antibiotics are indicated, with Penicillin and Flagyl being 98-99% effective in the below referenced review.  Nontoxic patient can be treated as an outpatient, while those who fail aspiration or I/D or are toxic may require surgical consultation.  

Want more in depth info?  Check out the podcast!

Battling Bad Science

Ever read a dogmatic news headline and had that niggling discomfort with the ‘science’ that passes for newsworthy ‘evidence’? OK, yes, me too. How about read an abstract in an area of interest and quoted the conclusions with conviction later to earn conversational credibility? Be honest, we’ve all done it. Check out this awesome, rapid-fire dissection of dogma and dodgy science by Epidemiologist Dr Ben Goldacre.

http://www.youtube.com/watch?v=h4MhbkWJzKk

An unusual hernia in an elderly

Introduction The evaluation of elderly with intra abdominal pathology on the emergency department (ED) is a challenging one, since they tend to have a very vague presentation. It is not unusual that the abdominal complains are fully at the background. The difficult evaluation and the high mortality rate makes this a very high risk group […]

Canadian FOAM of the Week 009: Sim and Choppers

Here we go again, it’s Canadian FOAM of the week episode 009 covering content posted since May 10th, 2013. What we may lack in quantity this week, we certainly make up for with quality in the featured posts.

Canadian FOAM of the Week: Sim and Choppers

Andrew Petrosoniak of Sim and Choppers is our FOAM of the week with his post on patient safety entitled “Patient safety strategies ready for primetime“. In this post, Andrew shares with us his thoughts on several recommendations published recently in the Annals of Internal Medicine on the use of checklists during critical patient care procedures.

Canadian FOAM: Honourable Mentions

  •  Eve Purdy has a couple of new posts up at Manu et Corde this week, the first is a fascinating discussion of how twitter/SoMe was integrated into a classroom dialog to enhance the learning environment and the second is part 2 of a fairly comprehensive list of “Neurology Resources for Medical Students“.
  • The SGEM brings us Episode #36 “Mac and CCBs” where Ken Milne answers the question “Do macrolides cause serious hypotension in patients on CCBs?”.

Canadian FOAM: Hat Tips

  • Danica Kindrachuk shares some entertaining vignettes from her attempts at studying neurology and other subjects over at Want2BeMD this week.

Author information

Joel D'Eath
Advanced Care Paramedic
I love tinkering with technology, the outdoors, photography and playing with my kids. In an attempt to delay the onset of dementia, I'm learning to play the bagpipes...

The post Canadian FOAM of the Week 009: Sim and Choppers appeared first on BoringEM and was written by .

Effective Learning Techniques Revealed

Interested in learning effectively?

Thought so.

Then you’ll want to read this free-to-access paper — it is a must read for every teacher and anyone serious about learning:

J. Dunlosky, K. A. Rawson, E. J. Marsh, M. J. Nathan, D. T. Willingham. Improving Students’ Learning With Effective Learning Techniques: Promising Directions From Cognitive and Educational Psychology. Psychological Science in the Public Interest, 2013; 14 (1): 4 DOI: 10.1177/1529100612453266 [Free Full Text]

Dunlosky and colleagues look at 10 commonly used revision techniques and assess the scientific evidence for their effectiveness. The key finding is that two techniques appear to be the most effective, namely “practice testing” and “distributed practice”. These techniques mean you have to actively test yourself (e.g. with flashcards) and revisit topics over time. Moderately useful techniques are ‘elaborative interrogation’ (explaining points or facts) and ‘self-explantion’ (showing how problems are solved) and ‘inter-leaved learning’ (switching between different types of learning). Other techniques — including summarization, highlighting and underlining, imagery while reading, keyword mnemonics, and rereading — are all low yield learning strategies.

Importantly, as Dunlosky says in ScienceDaily about the effective techniques, “these strategies are largely overlooked in the educational psychology textbooks that beginning teachers read, so they don’t get a good introduction to them or how to use them while teaching”. Mind you, if you’re an iTeachEM reader these findings will be of no great surprise to you — after all, you already know about the magic of spaced repetition and cognitive science and you’re already learning by spaced repetition.

The post Effective Learning Techniques Revealed appeared first on iTeachEM.

Long term weekly intramuscular ketamine for depression – a New Zealand case report

20130519-064812.jpg

THis month from the Journal of Palliative Medicine ( yes you should add this to your reading list!)
a case report from New Zealand, of the long term treatment of a woman with metastatic ovarian cancer and pre-existing major depressive disorder, weekly IMI ketamine 1mg/kg for her affective symptoms. The authors report good response to this treatment for 8 months!

Here is the link to the article
Long term mood response to repeat dose IMI ketamine


Filed under: FOAMEd, Rural medicine Tagged: case-report, depression, ketamine, new-zealand

Prehospital analgesia using intranasal S-Ketamine – case series from Sweden

20130519-061304.jpg

In the awesome Open access section of the Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine this month is this article on a case series of prehospital intranasal ketamine analgesia.

Here is the article link ( full text free!)
Prehospital intranasal S Ketamine analgesia case series

This adds to previous case reports like this one from Cliff Reid and colleagues
Case report: prehospital use of intranasal ketamine for paediatric burn injury

And a recent Victorian ED study of intranasal ketamine for paediatric limb injuries, reported here on ResusMe
Intranasal ketamine for kids – 1mg/kg?


Filed under: Emergency medicine and critical care, FOAMEd, Prehospital medicine Tagged: intranasal, ketamine, prehospital, Sweden

Pancreatitis CT…

A colleague pointed out an interesting CT on a patient with epigastric pain…

Pancreatitis CT2Pancreatitis CT1Pancreatitis CT 3

This CT shows stranding around the pancreas with fluid tracking in Gerota’s fascial plane.  What is Gerota’s fascia you say?

Gerota’s fascia (otherwise known as “Renal Fascia”) is the layer of connective tissue surrounding the kidneys and suprarenal glands.  Anterior to this fascial compartment is the prerenal space which contains the pancreas, ascending colon, descending colon, and the second-fourth portions of the duodenum.  Any inflammation with these organs can lead to fluid within Gerota’s fascia.  On the CT above this is demonstrated by the fluid stripe anterior to the left kidney on the middle image (sagittal plane)  and superior to the left kidney on the third image (coronal plane).  For an anatomic picture of Gerota’s fascia see the following Wikipedia reference:

Gerota’s Fascia

Author:  Russell Jones, MD

Image Contributor:  Tag Hopkins, MD

References

1.  Renal Fascia. http://en.wikipedia.org/wiki/Renal_fascia.  Accessed: 5/2013


Filed under: Abdomen/Pelvis, Abdomen/Pelvis, CT, Eponyms, Non-Trauma

Taking Apixaban (Eliquis) after completing Coumadin prevents recurrent DVT/PE (NEJM)

Apixaban (Eliquis) Prevents Recurrent DVT-PE Long-Term People with unprovoked venous thromboembolic disease (pulmonary embolism or deep venous thrombosis, or DVT) are at high risk for recurrence, and current ACCP guidelines advise consideration of “indefinite” anticoagulation. Warfarin (Coumadin) is a wonder drug efficacy-wise, reducing the risk of pulmonary embolism and deep venous thrombosis by ~90%. However, [... read more]

The post Taking Apixaban (Eliquis) after completing Coumadin prevents recurrent DVT/PE (NEJM) appeared first on PulmCCM.

top of the ladder…

The case.

It’s 9 o’clock at night. You are asked to review a 45 year old male on the ward for uncontrolled pain. He has a history of Crohn’s disease and is 24 hours post-laparotomy for small bowel resection & stoma formation. He is nil by mouth…

His current pain regime includes;

      • Paracetamol 1g q6h
      • Morphine PCA [2mg with 5min lockout] – 280mg used in prior 24 hours.
      • Ketamine infusion [8mg/hr]
      • Tramadol 100mg IV q6h
      • Ketorolac 10mg IM q6h
      • Bilateral surgically placed pre-peritoneal catheters with ropivocaine infusions (the left one ‘fell out’ 2 hours ago)….

On examination he is tachycardia and a little clammy. He has diffuse tenderness across the abdomen (L>>R) with percussion tenderness to the LLQ.

Here are mine….

      • Essentially he has reached the limit of his ‘conventional’ ward based analgesic therapy.
      • Is there an element of opiate induced hyperalgesia?!
      • Is there a post-operative surgical issue complicating the clinical picture?!
      • Next line therapy gets complicated & requires further monitoring or invasive techniques…

This patient represents a challenge. He has had multi-modal analgesia, but what do we do when we’ve reached the top of our analgesic ladder ?

      • Lignocaine infusion
      • Redo regional block (transversus abdominis plane [TAP] catheter)
      • Thoracic epidural (requires trip to OT)
      • Others [Dexmedetomidine]

Lignocaine Infusion.

Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials.
Can J Anaesth. 2011 Jan;58(1):22-37

Methods.

      • 29 studies with 1754 patients.
      • IV lignocaine versus placebo (or other comparator).

Results.

      • IV lignocaine lead to a statistically significant improvement (6 hours post-op) in pain at rest, with cough & with movement
      • Reduced opiate requirement by ~8mg morphine.
      • Other benefits included;
          • Improved time to flatus/faeces
          • Improvement in nausea & vomiting
          • Trend towards improved hospital length of stay (though not statistically significant).
      • Largest benefits seen in those having abdominal surgery.
      • Little data adverse reactions.

Similar data and results are found in…

Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery.
Surgery 2008; 95(11): 1331-1338

      • Small numbers – 8 RCTs & only 161 patients.
      • Post operative abdominal-surgical patients.
      • Loading dose 1.5-2mg/kg followed by an infusion of 1.5-3mg/kg/hour.

Difficult to extrapolate data to ED patients, but then there is this...

Effectiveness of intravenous lidocaine versus intravenous morphine for patients with renal colic in the emergency department.
Soleimanpour et al. BMC Urology 2012, 12:13

      • Randomized double-blinded trial
      • IV lignocaine (1.5mg/kg) vs Morphine (0.1mg/kg) in 240 ED patients with suspected renal colic.
      • Statistically significant reduction in pain scores in lignocaine groups over morphine group.
          • VAS10: Lig (1.83 ± 1.59) vs morph (2.89 ± 2.07) p=0.0001
          • VAS30: Lig (1.13 ± 1.15) vs morph (2.23 ± 1.57) p=0.0001
      • Similar side-effect rates.

 

Transversus abdominis plane (TAP) catheter.

      • A peripheral nerve block designed to anesthetize the nerves supplying the anterior abdominal wall (T6 to L1)
      • Local anesthetic is then injected between the internal oblique and transverse abdominis muscles just deep the fascial plane between (the plane through which the sensory nerves pass).

TAP block anatomy

Axial schematic taken from www.anesthesia-analgesia.org 

 

TAP USSUltrasound image of LA in TAP space. Taken from pie.med.utoronto.ca

http://www.youtube.com/watch?v=ab8Dvjauk_U

 

Thoracic Epidural.

      • Speaks for itself.
      • Requires consultation with Anaesthetics and Surgical specialties.
      • Facility dependent.

 

Dexmedetomidine.

      • Lots of evidence as a post-operative adjuvant analgesic.
          • Paediatric tonsillectomy, labour etc…
      • Usually requires monitored setting (likely HDU)
      • A concise summary can be found in the following paper…

Current role of dexmedetomidine in clinical anesthesia and intensive care.
Anesth Essays Res 2011;5:128-3

Recall; he was in agony & maxed out on his IV ward-based analgesics. He had received his subcutaneous heparin 2 hours earlier (for DVT prophylaxis) so the thoracic epidural option was out of the question (at least until 2-3am). A surgical review is arranged to consider the idea of a post-operative complication & in the meantime (at the advice of the on-call Anaesthetist) you give a test dose of IV lignocaine (“to see if the subsequent infusion will be worthwhile”). He receives 80mg of IV lignocaine (~1mg/kg) and his pain practically dissolves at the end of the needle.

He is reviewed over the night, and the infusion is avoided as he remains comfortable.

Unfortunately, his pain escalates over the next day with ongoing abdominal tenderness & guarding. A CT shows intraperitoneal fluid. He is taken back to theatre and found to have faecal soiling from a small bowel leak.

Important points:

      • Know the basics. Opiates plus all the necessary adjuncts.
      • Know a few trick shots and how to access them in your facility.
      • There is usually a reason for escalating pain, so think of the underlying pathology whilst simultaneously treating the symptoms.

DKA presenting as Wide Complex Tachcyardia

29-year-old man with history of type 1 diabetes mellitus and currently living in a hotel, presented to the emergency department with 2-weeks of feeling ill with had accelerated and was much worse over the last 2 days. This included a productive cough, subject fevers, and frequent vomiting. He was brought in by his brother, and the patient was appeared ill, was somnolent, confused, and only oriented to self. his blood pressure was 78/43 mmHg, pulse 146 bpm, respiratory rate 26, 37.2deg C, SpO2 96%. An finger stick blood glucose measurement read HIGH. A cardiogram was also obtained.

Case29--Presentation


This is a regular wide complex tachycardia. the first question you need to to determine in these cases is if the patient is stable or unstable. In this situation, the patient was hypotensive with altered mental status. He was electrically cardioverted using the synchronized setting and a voltage setting of 150 J. He was then immediately given 3 ampules of calcium gluconate and 3 ampules of sodium bicarbonate.

This is the correct treatment. The physicians inferred from the severe hyperglycemia that the patient may be hyperkalemic, which was the cause of the wide complex tachycardia. given that he was unstable electrical cardioversion was the first step, quickly followed by calcium to help stabilize the myocardium. The bicarbonate is given to facilitate the intracellular shift of potassium. The patient was additionally treatment with 2 L 0.9% saline bolus, 10 units SC insulin aspart were given.

Immediately after cardioversion the following cardiogram was obtained.

Case29--Post_Defibrillation

What is most impressive is the peaked T-waves consistent with hyperkalemia. His chemistry panel eventually returned which showed at presentation he had a glucose of 1120 mg/dl and a potassium of 6.6 mEq/L.

Androgue (Medicine 1986;65(3):163) created a formula to predict the potassium at admission in DKA.

K+ = 25.4 – (3.02 x pH) + (0.001 x glucose) + (0.028 x Anion Gap)

However in our case it under predicts the potassium, however the paper gives an excellent reviewing he mechanism of hyperkalemia in hyperglycemia.

Unfortunately the patient’s mental status did not improve significantly, and ultimately required orotracheal intubation and mechanical ventilation. He was admitted to the MICU where he continued on an insulin protocol overnight. About 10 hours after admission his anion gap had closed, and he was transitioned to long-acting insulin glargine. A repeat ECG at this time showed return of a normal sinus.

Case29--After_DKA_Treatment

The patient ultimately did well and was discharged from the hospital.

Use of Prehospital RSI predicts survivors after out of hospital cardiac arrest

IMG_0806

Here is the article

“Use of rapid sequence intubation predicts improved survival among patients intubated after out of hospital cardiac arrest”

What was the objective of the authors ? : To examine the relationship between advanced airway management and survival in a prehospital care system with RSI capability. Their hypothesis was that those patients who required RSI for prehospital intubation would be more likely to survive than those intubated without RSI drugs because of an underlying better prognosis.

How did they do this ? : Retrospective cohort analysis of a single large metropolitan EMS system in Seattle, between 2007-2011 using cardiac arrest registry and a separate advanced airway registry.

What did they find ?:  Those who did not get intubated had the best survival rates (71% left hospital). Those who got intubated with prehospital RSI did next best (48% left hospital). Those who got intubated without RSI did worse ( 11% left hospital)

What on earth does this all mean? :

Why do you need RSI to intubate a clinically dead person you ask? Good question..well this paper found that sometimes..in fact not infrequently you DO need RSI drugs to intubate someone in cardiac arrest! Why? Well think about it…it all depends on how long a person is in cardiac arrest for. Its not like the heart suddenly stops flow and everything stops working right? The paper notes that in almost half of arrest victims, there is still agonal gasping  soon after collapse as a result of ongoing brainstem activity. And if you start CPR immediately and restore some flow to the brainstem, then its not inconceivable that airway reflexes can be maintained even in full cardiac arrest. And here is where this paper makes sense…immediate CPR, restored brain perfusion..these are all things that likely contribute to better outcomes in cardiac arrest. So paradoxically the need to use RSI drugs to intubate is an associated factor that predicts those who are going to do better.

Now why does anyone care about this at all….well there have been prior prehospital studies ( notably this one by Hasegawa et al) to suggest that intubation was making things worse for cardiac arrest patients..not better as we all thought for years!

This paper refutes that assertion, saying that its not the intubation itself that is causing the worse outcomes, its the fact that if you can intubated a dead person without RSI drugs, they are of course going to do badly regardless!

Limitations of study : No supraglottic airway use employed during study period. Self reported airway registry data. Not easily extrapolated to other prehospital/EMS systems who do not have RSI capability.

 

 


Filed under: Online critical airway training, Prehospital medicine Tagged: arrest, cardiac, prehospital, RSI

RSI haemodynamics in the field

intubated-prehosp-vol-iconThe noxious stimulus of laryngoscopy & tracheal intubation can precipitate hypertension, tachycardia, and intracranial pressure elevation, risking exacerbation of brain injury or haemorrhage. Physicians from an English Helicopter Emergency Medical Service examined the response of heart rate and blood pressure to prehospital rapid sequence intubation (RSI). While a retrospective study, the haemodynamic data were prospectively recorded and documented using standard monitor printouts, and time of intubation could be accurately determined by the onset of capnography recordings. Their standardised system documents blood pressure recordings every three minutes. Etomidate and suxamethonium were used for RSI.

They report their findings:


A hypertensive response occurred in 79% (70/89) of patients. MAP exceeded the upper limit of estimated intact cerebral autoregulation (150 mmHg) in 18% (16/89) of cases and 9% (8/89) of patients had a greater than 100% increase in MAP and/or SBP. A single hypotensive response occurred. A tachycardic response occurred in 58% (64/110) of patients and bradycardia was induced in one.

Of note, 97 of the 115 patients had injuries that included head trauma.

The authors note that opioids are often co-administered during in-hospital RSI and that this may offset the haemodynamic stimulation, while possible increasing the complexity of the procedure in the prehospital environment. They have modified their pre-hospital anaesthesia standard operating procedure to include the use of an opioid and will report the associated outcomes and complication rates ‘in due course’.

This is interesting and important stuff, and something we should all be looking at in our respective prehospital critical care services.

The haemodynamic response to pre-hospital RSI in injured patients
Injury. 2013 May;44(5):618-23


BACKGROUND: Laryngoscopy and tracheal intubation provoke a marked sympathetic response, potentially harmful in patients with cerebral or cardiovascular pathology or haemorrhage. Standard pre-hospital rapid sequence induction of anaesthesia (RSI) does not incorporate agents that attenuate this response. It is not known if a clinically significant response occurs following pre-hospital RSI or what proportion of injured patients requiring the intervention are potentially at risk in this setting.

METHODS: We performed a retrospective analysis of 115 consecutive pre-hospital RSI’s performed on trauma patients in a physician-led Helicopter Emergency Medical Service. Primary outcome was the acute haemodynamic response to the procedure. A clinically significant response was defined as a greater than 20% change from baseline recordings during laryngoscopy and intubation.

RESULTS: Laryngoscopy and intubation provoked a hypertensive response in 79% of cases. Almost one-in-ten patients experienced a greater than 100% increase in mean arterial pressure (MAP) and/or systolic blood pressure (SBP). The mean (95% CI) increase in SBP was 41(31-51) mmHg and MAP was 30(23-37) mmHg. Conditions leaving the patient vulnerable to secondary injury from a hypertensive response were common.

CONCLUSIONS: Laryngoscopy and tracheal intubation, following a standard pre-hospital RSI, commonly induced a clinically significant hypertensive response in the trauma patients studied. We believe that, although this technique is effective in securing the pre-hospital trauma airway, it is poor at attenuating adverse physiological effects that may be detrimental in this patient group.

Are vasopressors effective therapy in calcium channel blocker overdose?

4 out of 5 stars

Critical Care Management of Verapamil and Diltiazem Overdose with a Focus on Vasopressors: A 25-Year Experience at a Single Center. Levine M et al. Ann Emerg Med 2013 May 1 {Epub ahead of print]

Abstract

This uncommonly interesting and thought-provoking study comes from the Department of Medical Toxicology at Banner Good Samaritan Medical Center in Phoenix. The authors note that in recent years, many toxicologists have suggested that hyperinsulinemic euglycemic therapy (HIT) is superior to vasopressors in the treatment of calcium channel blocker (CCB) toxicity. However, there have been no studies comparing the two modes of treatment.

At the authors’ institution — one that includes an in-hospital toxicology service — administration of high-dose vasopressors is a mainstay of treating these cases, and HIT apparently somewhat de-emphasized. To evaluate their perception that patients who present with CCB overdose almost always respond well to vasopressors, the authors retrospectively reviewed their experience of 25 years (1987 through 2012) with patients > 14 years of age who had laboratory-confirmed overdose to verapamil or diltiazem.

They identified 48 eligible patients, half with exposure to verapamil. Three patients received HIT, along with multiple vasopressors. In total, 33 patients received vasopressors (median 2 drugs, range 1-5). Maximum infusion rates included norepinephrine 100 μg/min, dopamine 100 μg/kg/min, epinephrine 150 μg/min, and phenylephrine 250 μg/min.

There was 1 death which apparently was caused by over-sedation for alcohol withdrawal and respiratory arrest, rather than the primary effects of CCB overdose. There were 8 possible or probable ischemic complications in 5 patients, all or most of which could be attributed to hypoperfusion from CCB overdose, rather than the effects of vasopressors. Except for the one patient who died, all the others survived neurologically intact.

The authors conclude that:

. . . management with high-dose vasopressors without hyperinsulemic euglycemic is not detrimental, given complete recovery in all but 1 patient. . . we recommend the use of initial fluid challenges and vasopressors as first choices in supporting blood pressure and treating shock caused by verapamil and diltiazem toxicity.

As the authors note in their “Limitations” section, these results may not be generalizable beyond their institution, which has extensive in-house toxicology resources. However, the paper makes one reconsider the effectiveness of vasopressors in these cases, especially when given in high doses. This is important reading, especially for toxicologists.

 

SMACC2013 Podcasts

Rural practice embraces the breadth of medicine. FOAMed can help us keep up to date and deliver “quality care, out there”.

We all know that critical illness does not respect geography – I have been inspired by the FOAMed coming out from the luminaries of the EM/Crit Care field – with lessons applicable to the rural doctor.

If you are a rural doctor – think about coming along to SMACC2014 on the Gold Coast in March next year- it’s ostensibly about “social media & critical care” – but the lessons are broader and applicable to rural doctors across the breadth of their work.

The SMACC2013 podcasts are rolling out and downloadable now from iTunes – click here to listen.

Meanwhile, stop worrying, dive in and enjoy the FOAMed…

 

 


The Poison Review 2013-05-18 01:08:32

4 out of 5 stars

Critical Care Management of Verapamil and Diltiazem Overdose with a Focus on Vasopressors: A 25-Year Experience at a Single Center. Levine M et al. Ann Emerg Med 2013 May 1 {Epub ahead of print]

Abstract

This uncommonly interesting and thought-provokeng study comes from the Department of Medical Toxicology at Banner Good Samaritan Medical Center in Phoenix. The authors note that in recent years, many toxicologists have suggested that hyperinsulinemic euglycemic therapy (HIT) is superior to vasopressors in the treatment of calcium channel blocker (CCB) toxicity. However, there have been no studies comparing the two modes of treatment.

At the authors’ institution — one that includes an in-hospital toxicology service — administration of high-dose vasopressors is a mainstay of treating these cases, and HIT apparently somewhat de-emphasized. To evaluate their perception that patients who present with CCB overdose almost always respond well to vasopressors, the authors retrospectively reviewed their experience of 25 years (1987 through 2012) with patients > 14 years of age who had laboratory-confirmed overdose to verapamil or diltiazem.

They identified 48 eligible patients, 24 with verapamil exposure.

 

Sick Notes

My last post on GANFYD syndrome created some questions about the whole sick note system in Australia, which are perhaps worth exploring.

Let me be absolutely clear – doctors have no problem issuing sick notes when appropriate – such as the patient who presents with a lower respiratory tract infection and, at the time of consult, requests a note as unable to work 9or poses a health risk to co-workers). Similarly the patient with a broken limb who may be unable to perform his/her duties. Nor is there a problem with completing notes for WorkCover compensable injury – a prescribed medical certificate with details of illness and proposed treatment/rehabilitation is helpful for both employer and worker to achieve a successful return to duties.

The AMA and RACGP have issued guidance on sick notes – which you can access from the links below. A read of these should alert the doctor to the requirements for

- confidentiality
- accuracy
- veracity

However, there are still a few grey areas. Let’s take an example

A patient attends on Thursday 18/3 with a LRTI since the previous Monday. You examine them, confirm the presence of a LRTI and advise three days of time off work.

They would receive a note along the lines of :

“TO WHOM IT MAY CONCERN
I write to confirm that I examined PATIENT X on 18/3 and diagnosed them with a medical condition. He/she will be unable to work from 18/3 to 20/3.
Yours sincerely
Dr Y”

There you go – this note confirms their attendance and examination on 18/3, your advice for time off for three days…and as was part of the patient consult for their illness, is Medicare-compensable. It doesn’t specify the reason, other than ‘medical condition’ as the patient has a right to confidentiality.

The following Monday, the patient rings in (or attends) requesting a further note. They feel fine and have returned to work. But their employer now wants “a note to explain why they were ill, to cover the time off from previous Monday and to guarantee that they are fit for work duties.” The patient is bemused as they feel fine.

This is a classic “GANFYD” and raises several issues

- the importance of doctor-patient confidentiality
- the request for a note to cover time off that the doctor cannot confirm
- the request for a determination of ‘fitness for work’
- the fact that the employer requests this information, not the patient…as usual the doctor charges a private fee – but should there be a Medicare rebate?

There is a growing concern about GANFYD syndrome (“get a note from your doctor” syndrome) – the ever-increasing requests from employers/outside agencies for a note. Usually these requests are NOT at the patient’s wish – instead they are requested by organisations who wish to either absolve themselves of responsibility or to fulfil a bureaucratic, not a medical requirement. Max Kamien writes well on this and gave an excellent interview with the ABC.

The doctor may write something along the lines of

“To WHOM IT MAY CONCERN.
Patient X attended the clinic today at the request of his employer. I direct you to my previous note confirming sickness from 18/3 to 20/3 due to a medical condition. Patient X tells me that he/she was unable to work from the previous Monday 15/3 and now feels fit to return to work. I have no reason to doubt his/her veracity.
Love & kisses, Dr Y”

…and then the doctor might struggle to determine whether employer or patient pays for the consult. I see no reason to discount my fee for a professional service (would a lawyer?), but if there was genuine hardship the doctor may be inclined to bulkbill the consult to Medicare…so the taxpayer is effectively paying for the employer’s request for a note. Hardly a good use of the Medicare system, propping up an unnecessary doctors consultation for an essentially bureaucratic matter. Note that pharmacists can issue sick notes (for a fee) – but that no Medicare rebate applies. So unless there is a genuine medical need, I would tend to bill privately and encourage the worker to present the bill to their employer.

Later that day the doctor receives (via his/her receptionist), an angry phone call from the Human Resources manager at the patient’s workplace. They express dissatisfaction that the ‘sick note’ does not explain why the patient was unwell, nor does it cover them as an employer should the worker be unfit for return to work. They demand an explanation of the precise nature of the medical condition and that the doctor provide a statement that the worker is fit for their duties which apparently include maintenance of a sausage-factory production line and “insufflator-hyfrecator cleansing technician”. They also complain that the doctor has suggested that the workplace pay for the previous note.

How do you respond?

First up, unless there is signed consent from the patient, the employer has no right to details of the medical condition (it may be blindingly obvious in case of a broken arm or amputation, but this may not dissuade HR). Demand that the employer furnish you with the patient’s written consent. Next they require an assessment of the worker’s fitness to perform his/her duties. We are now firmly in the territory of providing an expert occupational medical opinion. Are you prepared to do this? I always imagine how I would defend myself if the patient came to harm and was being interrogated by a barrister or the Coroner. To be absolutely certain, I might require a full hour long occupational medical examination, a workplace site assessment or perhaps referral to an occupational physician for a specialist opinion. I won;t tell you my hourly rate, but for this sort of private medical one may be guided by a lawyer’s fees for appropriate billing (taking into account training, professional qualifications, admin costs etc)

All this takes time, is taking the Doctor away from core business (being a doctor, seeing sick patients) and is being requested by the employer – who needs to be prepared to pay for it. It is a hell of a lot more than ‘just a note’ and is nothing to do with Medicare.

As always, I would encourage the use of the universal GANFYD deflector letter – originally from the UK, but easily adapted to Australian circumstances. It is included below.

GANFYDS

One should bear in mind that the vast majority of GPs are private practitioners. They charge fees for consults and the patient may be able to claim back a portion of those fees under the Medicare rebate system.

Generally requests for notes or medical reports are NOT a Medicare service, more so when requested by the employer.

If there is doubt, or if the employer (or another agency) requests a medical report then be prepared to deploy the GANFYD deflector.

Otherwise you will drown in unnecessary paperwork – and patients who do need to see you will be unable to do so. And keep Medicare out of it, unless there is an underlying medical need for the consult. We are in deficit and health costs are rising – such requests should not be propped up by the taxpayer unless appropriate.

As Prof Max Kamien has pointed out, it’s unlikely anyone REALLY needs these certificates – they are fulfilling a bureaucratic or ‘cover your ass’ need. He reckon’s he’s written over 20,000 bland certificates and only had 2 challenged. Indeed there is an industry in providing fake certificates – such as DoctorsNoteStore.com !

Consider the following examples:

The 16yo school child who misses an exam due to vomiting during class, witnessed by teacher. She sensibly goes home and recovers within a few hours. Three days letter needs to book an urgent appointment as ‘school requires a note’

[Should be able to self-certify. Not needing to see doctor at time of illness. School should be able to act based on student, parent or even teacher's assessment.]

The worker who was unable to work on a Friday due to a migraine. Presents on the following Tuesday on instructions of employer who ‘want a note so say was unwell on Friday – wouldn’t normally need a note but because was sick on day prior to weekend, employer needs a note”

[worker should be able to self-certify. Doctor unable to determine veracity of illness on Friday when examined 4 days later and now well. Can generate bland note to this effect - but charge privately to employer. Legislation to allow self-certification would be helpful]

The employer who requests a note “stating that worker is fit to return to duty” after a previous injury for a non-work related injury (eg: broken toe).

[this is a request for an occupational medical assessment. The assessor needs to be fully informed of the worker's duties and perform an examination directed at their fitness to perform these tasks. Needs will vary eg: desk worker vs deep-sea diver vs professional dancer. A site visit, list of all work duties and a good hour long medical plus a few hours for report/workplace assessment would be required at commensurate rates]

The patient who requires a note from gym/diet agency/sports body stating ‘that is medically fit to undertake task’ eg: parachute jump for charity, crash diet, gym programme, diving

[the agency is essentially asking the doctor to take responsibility for an activity over which they have no control. Two choices - either a quick note (with signed consent) confirming the patient's past medical history and suggesting that the agency make own assessment of risk...or a full on medical examination targeted to task proposed (preferably by a clinician with experience in the field), privately charged...with same comment that risk remains that of individual and agency]

THE UNIVERSAL GAFYD DEFLECTOR

Date:

Dear Sir/Madam

Regarding Name:

Patient Address:

My patient has requested that I send you details of his/her medical history in so far as this is related to employment / workplace needs. I would be grateful if you would confirm your need for this information and complete the details below:

Precise information required (please be specific):

I consent to the above information being given by my GP to my employer.

Patient’s signature:
Print Name :
Date :

Date by which GP response is required (at least 7 days from receipt of your reply to this request):

The employer accepts responsibility for the fee payable for this service depending on requirements. This may require payment for a clinical examination, generation of medical report, specialist consultation & investigation, workplace assessment and administrative fees.

PLEASE NOTE THAT THIS IS NOT A MEDICARE-COMPENSABLE SERVICE AND THAT THE EMPLOYER IS RESPONSIBLE FOR ALL FEES (fee schedule attached)

Signature (employer):

Date :

Please print name and position:

In the event that this information is not required I will assume that the patient themselves can supply you with all necessary details.

Yours faithfully etc

Dr XXXX

LINKS

AMA Guidelines for issuing sickness certificates

RACGP – Sickness Certification

The Sick Saga of Sickness Certificates

Pharmacists can issue sick notes

Doctor’s certificates are a sick joke

Should GPs have to write sick notes?